Two-year cross-sectional studies reveal that single, young MSMs in Shenzhen, China are at high risk for HIV infection
Two-year cross-sectional studies reveal that single, young MSMs in Shenzhen, China are at high risk for HIV infection
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为期两年的横断面研究表明，中国深圳的单身年轻男男性接触者感染艾滋病毒的风险很高。
DOI：
10.1186/s12985-019-1189-6
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发表时间：
2019-06-22
期刊：
影响因子：
4.8
通讯作者：
Li, Lin
中科院分区：
文献类型：
--
作者：
Jia, Dijing;Zhao, Jin;Li, Lin
背景深圳市是一个发展迅速的地区，流动人口众多，给艾滋病的控制带来了困难。系列横断面研究有助于预测流行趋势。本研究采用两个平行的横断面研究，比较深圳市2013年和2015年HIV流行病学的变化。方法随机抽取深圳市250例新报告的HIV阳性病例。在知情同意的情况下收集社会人口信息。采用巢式RT-PCR扩增全长gag基因和部分pol基因，然后进行测序和系统发育分析。同时分析抗HIV药物耐药基因型。比较2013年和2015年艾滋病毒流行的特征以确定模式。结果与2013年相比，2015年单身、年轻的男男性接触者比例急剧增加。多种亚型，包括CRF07_BC（36.4%），CRF01_AE（34.1%），CRF 55_01 B（10.2%），B类（6.4%）、CRF08_BC（3.4%）、CRF59_01B（0.9%）、C（0.7%）、D（0.2%）、CRF68_01B（0.2%）、CRF67_01B（0.2%）和独特重组形式（URF，7.3%）。深圳地区流行株与国内其他地区流行株之间的亲缘关系较近。没有发现局限于单个年轻MSM的流行聚集性。0.4 2013年和2015年分别有2.8%的毒株携带传播性耐药突变。结论深圳市HIV流行病学变化明显，间隔时间较短。因此，有必要对深圳市的艾滋病疫情进行经常性监测。单身、年轻男男性接触者已成为深圳市HIV感染的高危人群，应作为深圳市HIV预防和行为干预的重点人群。
BackgroundShenzhen City is a rapidly growing area with a large number of floating populations, thus making it difficult to control HIV. Serial cross-sectional studies are helpful for the prediction of epidemiological tendency. In this study, two parallel cross-sectional studies were compared to explore changes in HIV epidemiology in Shenzhen, China.MethodsTwo hundred and fifty newly reported HIV-positive cases were randomly selected in Shenzhen City in 2013 and 2015. Socio-demographical information was collected with informed consent. Full-length gag and partial pol genes were amplified using nested RT-PCR followed by sequencing and phylogenetic analysis. The genotypes of anti-HIV drug resistance were also analyzed. The characteristics of the HIV epidemics of 2013 and 2015 were compared to identify patterns.ResultsThe proportion of single, young MSMs dramatically increased in 2015 compared to 2013. Many subtypes, including CRF07_BC (36.4%), CRF01_AE (34.1%), CRF55_01B (10.2%), B (6.4%), CRF08_BC (3.4%), CRF59_01B (0.9%), C (0.7%), D (0.2%), CRF68_01B (0.2%), CRF67_01B (0.2%), and unique recombinant forms (URFs, 7.3%), were identified. Close phylogenetic relationships between strains prevalent in Shenzhen and other areas of China was observed. No epidemic cluster confined to single, young MSMs was identified. 0.4 and 2.8% of the strains contained transmitted drug-resistant mutations in 2013 and 2015, respectively.ConclusionAlthough the interval period is short, changes in HIV epidemiology in Shenzhen City are distinct. Frequent surveillance of HIV epidemics in Shenzhen City is thus necessary. Single, young MSMs have become a high-risk population for HIV infection and should be considered as focus population for HIV prevention and behavior intervention in Shenzhen City.