Morphological computed tomography features of surgically resectable pulmonary squamous cell carcinomas: Impact on prognosis and comparison with adenocarcinomas
Morphological computed tomography features of surgically resectable pulmonary squamous cell carcinomas: Impact on prognosis and comparison with adenocarcinomas
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DOI：
10.1016/j.ejrad.2014.04.019
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发表时间：
2014-07-01
影响因子：
3.3
通讯作者：
Puderbach, Michael
中科院分区：
文献类型：
--
作者：
Santos, Marcel Koenigkam;Muley, Thomas;Puderbach, Michael
目的：描述肺鳞状细胞癌（SQCC）的形态学计算机断层扫描（CT）功能提交给治疗性切除;这些功能与患者的结果相关;并与肺腺癌（ADC）进行比较。材料和方法：两名胸部放射科医生回顾性评价了2002年至2008年切除的123例SQCC患者的CT检查。肿瘤的大小、位置（中央与外周）、形状、边缘、衰减、增强、钙化、空洞、内部空气支气管造影和胸膜标签的存在通过共识分配。特征的患病率与患者的生存数据和先前研究的ADC手术切除的人口在同一时间periods.Results：空化负相关的总体（风险比= 3.04），疾病特异性（HR = 3.67）和无病生存（HR= 2.69），独立于年龄，性别，肿瘤病理分期，大小和位置。与ADC值相比，SQCC表现为形态、边界、强化、强化不同，空洞较多，内支气管充气征少见，胸膜标签较少。差异也显着比较只有外周型tumors.Conclusions：空洞在CT是一个独立的和阴性预测因素SQCC。描述了SQCC和ADC的不同CT形态学特征。肺部病变的影像学评价不应局限于测量和解决邻近结构的侵犯。充分的影像学特征不仅有助于鉴别良恶性病变和确定恶性分期，还可以提示组织学亚型，改善肺癌患者的预后评估。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Objective: To characterize the morphological computed tomography (CT) features of pulmonary squamous cell carcinomas ( SQCC) submitted to therapeutic resection; to correlate these features with patients' outcomes; and to compare with pulmonary adenocarcinomas (ADC).Materials and methods: Two chest radiologists retrospectively evaluated CT exams of 123 patients with SQCC resected between 2002 and 2008. Tumors' size, location (central vs. peripheral), shape, margins, attenuation, enhancement, presence of calcification, cavitation, internal air bronchograms and pleural tags were assigned by consensus. Prevalence of features was compared with patients' survival data and a previously studied population of ADC surgically resected at the same time period.Results: Cavitation correlated negatively with overall (hazard ratio= 3.04), disease-specific (HR = 3.67) and disease-free survival (HR= 2.69), independent from age, gender, tumor pathological stage, size, and location. In relation to ADC, SQCC presented different shape, margins, attenuation, enhancement, with more cavitation, rare internal air bronchograms, and less pleural tags. Differences were also significant when comparing only the peripheral type of tumors.Conclusions: Cavitation at CT was an independent and negative predictive factor for SQCC. Different CT morphological features were described for SQCC and ADC. Image evaluation of lung lesions should go beyond measuring and addressing adjacent structures invasion. Adequate imaging characterization not only helps to differentiate benign versus malignant disease and to determine malignancy staging, it may also imply the histologic subtype and improve the prognostic assessment of lung cancer patients. (C) 2014 Elsevier Ireland Ltd. All rights reserved.