The effect of repeated administration of anti-depressant drugs on the thyrotropin-releasing hormone (TRH) content of rat brain structures
The effect of repeated administration of anti-depressant drugs on the thyrotropin-releasing hormone (TRH) content of rat brain structures
复制标题
抗抑郁药物重复给药对大鼠脑结构促甲状腺素释放激素（TRH）含量的影响
DOI：
10.1016/0306-4530(90)90023-3
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发表时间：
1990
影响因子：
3.7
通讯作者：
L. Jaworska
中科院分区：
文献类型：
--
作者：
E. Przegaliński;L. Jaworska
本研究探讨了抗抑郁药丙咪嗪，阿米替林，西酞普兰和米安色林（10 mg/kg PO，每日两次，连续14天）重复治疗对大鼠几种脑结构（大脑皮质，杏仁核+梨状皮质，海马，丘脑，纹状体和下丘脑）促甲状腺激素释放激素（TRH）水平的影响。阿米替林引起纹状体和中脑核TRH含量显著增加。西酞普兰和米安色林仅在纹状体中产生较小但显着的TRH含量增加，而丙咪嗪并没有显着影响任何大脑结构中的TRH浓度。急性给药的抗抑郁药物对丘脑核或纹状体中TRH浓度无显著影响。这些结果表明，由抗抑郁药物引起的脑TRH的变化与其治疗活性无关。
The present study investigated the effect of repeated treatment with the antidepressant drugs imipramine, amitryptyline, citalopram and mianserin (10 mg/kg PO, twice daily for 14 days) on levels of thyrotropin-releasing hormone (TRH) in several brain structures (cerebral cortex, amygdala + pyriform cortex, hippocampus, nucleus accumbens, striatum and hypothalamus) of the rat. Amitriptyline caused a marked increase in the TRH content in the striatum and nucleus accumbens. Citalopram and mianserin produced a smaller but significant increase in the TRH content in the striatum only, while imipramine did not significantly affect the TRH concentrations in any of the brain structures. None of the antidepressant drugs administered acutely significantly affected the TRH concentrations in the nucleus accumbens or the striatum. These results indicate that changes in brain TRH induced by antidepressant drugs are not related to their therapeutic activity.