Influence of space-filling materials in subantral bone augmentation: blood clot vs. autogenous bone chips vs. bovine hydroxyapatite
Influence of space-filling materials in subantral bone augmentation: blood clot vs. autogenous bone chips vs. bovine hydroxyapatite
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DOI：
10.1111/j.1600-0501.2010.02069.x
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发表时间：
2011-05-01
影响因子：
4.3
通讯作者：
Rompen, Eric
中科院分区：
文献类型：
--
作者：
Lambert, France;Leonard, Angelique;Rompen, Eric
目的本研究的第一个目的是比较使用不同间隙填充物的兔鼻窦下骨再生的短期和长期三维体积稳定性。第二个目标是定性和定量评估的早期骨形成过程和长期行为的再生bone.Materials和MethodsFifteen兔进行了双窦升降机程序使用：血块（凝块），自体骨芯片（汽车）和牛羟基磷灰石（BHA）。在1周、5周和6个月时对动物实施安乐死。对样本进行X射线显微断层扫描和组织学检查。计算不同时间点骨增量的变化。定性分析，使用7 μ m的部分和定量组织形态计量学分析进行了使用扫描电子显微镜。结果从基线（100%）到5周，增加的体积下降到17.3%（凝块），57.6%（自动）和90.6%（BHA）。6个月后，仅发现初始体积的19.4%（凝块）和31.4%（自动），而BHA组（84%）保持更稳定。在1周时，可以在三组中沿着骨壁观察到初始成骨过程。第5周时，尽管体积显著下降，但Clot和Auto组的新形成骨密度高于BHA组。6个月时，三组的骨密度在统计学上相似。然而，6个月后，当使用BHA作为间隙填充物时，新形成的骨（再生区域）侵入的表面显著更高。BHA组生物材料面积由1周时的42.7%降至5周时的40%和6个月时的34.9%，6个月时复合再生组织（骨+BHA）密度> 50%。尽管如此，凝块和Auto组的扩张量下降，而BHA组保持稳定。可缓慢吸收的生物材料可能适用于鼻窦下骨填充，以防止再扩张过程并增加再生组织的密度。引用本文：Lambert F，伦纳德A，Drion P，Sourice S，Layrolle P，Rompen E.上颌窦下骨填充术中空间填充材料的影响：血凝块、自体骨片和牛羟基磷灰石。Res. 22，2011; 538-545doi：10.1111/j.1600-0501.2010.02069.x.
AimThe first objective of the present study was to compare the short- and long-term 3D volume stability of sub-sinusal bone regeneration in rabbits using different space fillers. The second objective was to assess qualitatively and quantitatively the early bone formation process and long-term behavior of the regenerated bone.Materials and methodsFifteen rabbits underwent a double sinus lift procedure using: blood clot (Clot), autogenous bone chips (Auto) and bovine hydroxyapatite (BHA). Animals were euthanized at 1 week, 5 weeks and 6 months. Samples were subjected to X-ray microtomography and histology. Variations in the volume of bone augmentations were calculated at different time points. Qualitative analysis was performed using 7 mu m sections and quantitative histomorphometric analyses were carried out using scanning electron microscopy.ResultsFrom baseline (100%) to 5 weeks, the augmented volumes declined to 17.3% (Clot), 57.6% (Auto) and 90.6% (BHA). After 6 months, only 19.4% (Clot) and 31.4% (Auto) of initial volumes were found, while it remained more stable in the BHA group (84%). At 1 week, an initial osteogenesis process could be observed in the three groups along the bone walls. At 5 weeks, despite a significant decline in the volume, newly formed bone density was higher with Clot and Auto than with BHA. At 6 months, bone densities were statistically similar in the three groups. However, after 6 months, the surface invaded by newly formed bone (regenerated area) was significantly higher when BHA was used as space filler. In the BHA group, the biomaterial area slightly decreased from 42.7% (1 week) to 40% (5 weeks) and 34.9% (6 months) and the density of the composite regenerated tissue (bone+BHA) reached > 50% at 6 months.Conclusions and clinical implicationsThe three space fillers allowed bone formation to occur. Nevertheless, augmented volumes declined in the Clot and Auto groups, while they remained stable with BHA. A slowly resorbable biomaterial might be suitable in sub-sinusal bone augmentation for preventing the re-expansion process and for augmenting the density of the regenerated tissues.To cite this article:Lambert F, Leonard A, Drion P, Sourice S, Layrolle P, Rompen E. Influence of space-filling materials in subantral bone augmentation: blood clot vs. autogenous bone chips vs. bovine hydroxyapatite.Clin. Oral Impl. Res. 22, 2011; 538-545doi: 10.1111/j.1600-0501.2010.02069.x.