Controlled release of diclofenac sodium from polylactide acid-based solid dispersions prepared by hot-melt extrusion
Controlled release of diclofenac sodium from polylactide acid-based solid dispersions prepared by hot-melt extrusion
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DOI：
10.1080/09205063.2016.1141273
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发表时间：
2016-04-12
影响因子：
3.6
通讯作者：
Guo, Shaoyun
中科院分区：
文献类型：
--
作者：
Chen, Rong;Li, Genlin;Guo, Shaoyun
本文采用热熔挤出法制备了以聚乳酸（PLA）为基质的药物递送系统。双氯芬酸钠（DS）用作模型药物。使用聚乙二醇（PEG，分子量为6000）和十二烷基硫酸钠（SDS）作为释放速率调节剂。对于 PLA/PEG/DS 共混物，较高量的 PEG 和 DS 增强了 DS 的释放。 PLA/PEG/DS共混物中添加SDS后，DS和PEG的分散性得到显着改善。与相同载药量的PLA/PEG/DS共混物相比，由于SDS的存在，PLA/PEG/DS/SDS的药物释放行为被显着抑制。并实现了DS的可控线性释放。
In this paper, hot-melt extrusion was applied to prepare drug delivery systems using polylactide acid (PLA) as the matrix. Diclofenac sodium (DS) was used as a model drug. Polyethylene glycol (PEG, molecular weight is 6000) and sodium dodecyl sulfate (SDS) were used as the release rate modifiers. For the PLA/PEG/DS blends, the release of DS was enhanced with higher amounts of PEG and DS. After the addition of SDS to the PLA/PEG/DS blends, the dispersion of DS and PEG was significantly improved. Compared to the PLA/PEG/DS blends with the same drug loading, the drug release behavior of PLA/PEG/DS/SDS was remarkably suppressed due to the presence of SDS. And a controllable linear release of DS was achieved.