Serum IFNγ-induced protein 10 (IP10/CXCL10): association with asthma exacerbations and severity in children
Serum IFNγ-induced protein 10 (IP10/CXCL10): association with asthma exacerbations and severity in children
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DOI：
10.1080/02770903.2021.1999465
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发表时间：
2021-10-28
影响因子：
1.9
通讯作者：
Hanna，Mariam Onsy F.
中科院分区：
文献类型：
--
作者：
Osman，Hanan M.;El Basha，Noussa Ragab;Hanna，Mariam Onsy F.
目的哮喘是一种慢性呼吸道疾病，趋化因子在其中协调呼吸道炎症并决定其严重程度。本研究旨在从蛋白水平研究CXCR3配体家族成员趋化因子γ诱导蛋白10 kDa(IP10/CXCL10)在儿童血清中的表达，以探讨CXCL10与儿童哮喘发作的关系。方法对42例哮喘急性加重期患者和43例缓解期患者血清CXCL10水平进行检测。结果哮喘急性发作期患者血清CXCL10水平明显高于缓解期患者(p<； 0.001)。此外，与中度和轻度疾病相比，重度哮喘患者的CXCL10值升高(p<； 0.001)。特应性哮喘患者血清CXCL10水平显著高于非特应性哮喘患者(p= 0.027)，而非特应性哮喘患者和部分控制性哮喘患者的CXCL10值均高于正常对照组(p= 0.046)。结论CXCL10可作为哮喘加重和哮喘症状加重的炎症血清标志物。CXCL10水平代表哮喘的临床严重程度。
ObjectiveAsthma is a chronic disorder of the airways, in which chemokines coordinate airway inflammation and determine its severity. We aimed to study the chemokine interferonγ–inducible protein 10 kDa (IP10/CXCL10), a member of the CXC receptor 3 (CXCR3) ligand family, at the protein level in the serum of children, to evaluate the association between CXCL10 and exacerbations of childhood asthma.MethodsPatients experiencing an asthma exacerbation (42 patients) and stable patients (43 patients) were investigated for serum CXCL10 levels.ResultsPatients with an asthma exacerbation expressed significantly higher CXCL10 levels in the serum than stable patients (p< 0.001). Additionally, CXCL10 values were elevated in severe asthma compared with moderate and mild disease (p< 0.001). In patients experiencing asthma exacerbations, higher values of CXCL10 were observed in atopic patients compared with non-atopic patients (p= 0.027) and in uncontrolled and partly controlled patients compared with controlled patients (p= 0.046).ConclusionsCXCL10 is proposed as an inflammatory serum marker for asthma exacerbations and worsening asthma symptoms. The levels of CXCL10 are representative of the clinical severity of asthma.