Outcomes in pregnancies with a confined placental mosaicism and implications for prenatal screening using cell-free DNA
Outcomes in pregnancies with a confined placental mosaicism and implications for prenatal screening using cell-free DNA
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DOI：
10.1038/s41436-019-0630-y
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发表时间：
2020-02-01
影响因子：
8.8
通讯作者：
Prefumo, Federico
中科院分区：
文献类型：
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作者：
Grati, Francesca Romana;Ferreira, Jose;Prefumo, Federico
目的探讨限制性胎盘马赛克(CPM)与不良妊娠结局的关系。方法采用回顾性队列研究方法，对罕见的常染色体三体(大鼠)或四倍体的妊娠合并和不合并CPM的结局进行评估。考虑因素包括出生体重、分娩时胎龄、胎儿生长受限(FGR)、阿普加评分、新生儿重症监护入院、早产和妊娠高血压疾病。结果总共收集了181例妊娠合并CPM患者和757例对照组。69%的病例(n=124)和62%的对照组(n=468)可获得结果信息。涉及16三体(T16)的CPM与新生儿体重增加相关
Purpose To assess the association between confined placental mosaicism (CPM) and adverse pregnancy outcome. Methods A retrospective cohort study was carried out evaluating the outcome of pregnancies with and without CPM involving a rare autosomal trisomy (RAT) or tetraploidy. Birthweight, gestational age at delivery, fetal growth restriction (FGR), Apgar score, neonatal intensive care admission, preterm delivery, and hypertensive disorders of pregnancy were considered. Results Overall 181 pregnancies with CPM and 757 controls were recruited. Outcome information was available for 69% of cases (n = 124) and 62% of controls (n = 468). CPM involving trisomy 16 (T16) was associated with increased incidence of birthweight