High-intensity interval training without weight loss improves exercise but not basal or insulin-induced metabolism in overweight/obese African American women
High-intensity interval training without weight loss improves exercise but not basal or insulin-induced metabolism in overweight/obese African American women
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DOI：
10.1152/japplphysiol.00306.2015
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发表时间：
2015-08-15
影响因子：
3.3
通讯作者：
Albu, Jeanine B.
中科院分区：
文献类型：
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作者：
Arad, Avigdor D.;DiMenna, Fred J.;Albu, Jeanine B.
这项随机对照临床试验的目的是确定14周高强度间歇训练（HIIT）干预和体重稳定对久坐、绝经前、非糖尿病、超重/肥胖的非裔美国妇女的代谢灵活性、胰岛素敏感性和心肺功能的影响。28名受试者被分配到两组中的一组：HIIT，每周进行三次四次高强度自行车间隔，或对照组（CON），保持正常的身体活动水平。控制所有受试者的饮食，以确保体重稳定。干预前后（前/后），受试者完成递增循环试验以限制耐受性，并在10天高脂控制喂养期后，进行正常血糖-高胰岛素钳夹试验以确定胰岛素敏感性和底物氧化。HIIT的9名成员（年龄，29 +/- 4岁;体重，90.1 +/- 13.8 kg）和CON的11名成员（年龄，30 +/- 7岁;体重，85.5 +/- 10.7 kg）完成了研究。HIIT的耐受限度增加（术后，1，124 +/- 202 s;术前，987 +/- 146 s; P < 0.05），气体交换阈值（后，1.29 +/- 0.34升/分钟;前，0.97 +/- 0.23升/分钟; P < 0.05），并且与CON相比，在相同的绝对次最大功率下脂肪氧化（所有情况下组与时间相互作用P < 0.05）。然而，HIIT组与CON组相比，峰值耗氧量（（V）超过doto（2 peak））、胰岛素敏感性、胰岛素刺激期间游离脂肪酸抑制和代谢灵活性的变化没有差异。高强度间歇训练与体重稳定性增加了糖尿病进展风险受试者的运动脂肪氧化和耐受性，但在吸收后或胰岛素刺激状态下没有改善胰岛素敏感性或脂肪氧化。
The purpose of this randomized controlled clinical trial was to determine the effect of a 14-week high-intensity interval training (HIIT) intervention with weight stability on metabolic flexibility, insulin sensitivity, and cardiorespiratory fitness in sedentary, premenopausal, nondiabetic, overweight/obese African American women. Twenty-eight subjects were allocated to one of two groups: HIIT, which performed three sessions per week of four high-intensity cycling intervals, or a control group (CON), which maintained their normal level of physical activity. Diet was controlled for all subjects to ensure weight stability. Preand postintervention (pre/post), subjects completed an incremental cycling test to limit of tolerance and, following a 10-day high-fat controlled feeding period, a euglycemic-hyperinsulinemic clamp to determine insulin sensitivity and substrate oxidation. Nine members of HIIT (age, 29 +/- 4 yr; body mass, 90.1 +/- 13.8 kg) and eleven members of CON (age, 30 +/- 7 yr; body mass, 85.5 +/- 10.7 kg) completed the study. HIIT experienced an increased limit of tolerance (post, 1,124 +/- 202 s; pre, 987 +/- 146 s; P < 0.05), gas exchange threshold (post, 1.29 +/- 0.34 liters/min; pre, 0.97 +/- 0.23 liters/min; P < 0.05), and fat oxidation at the same absolute submaximal work rate compared with CON (P < 0.05 for group-by-time interaction in all cases). However, changes in peak oxygen consumption ((V) over doto(2peak)), insulin sensitivity, free fatty acid suppression during insulin stimulation, and metabolic flexibility were not different in HIIT compared with CON. High-intensity interval training with weight stability increased exercise fat oxidation and tolerance in subjects at risk for diabetic progression, but did not improve insulin sensitivity or fat oxidation in the postabsorptive or insulin-stimulated state.