TISSUE REGENERATION BY USE OF COLLAGEN-GLYCOSAMINOGLYCAN COPOLYMERS
TISSUE REGENERATION BY USE OF COLLAGEN-GLYCOSAMINOGLYCAN COPOLYMERS
复制标题
DOI：
10.1016/0267-6605(92)90098-e
复制
发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
YANNAS I V
中科院分区：
文献类型：
--
作者：
YANNAS I V
细胞外基质的简单化学类似物已经通过糖胺聚糖与I型胶原的接枝共聚来合成。这些胶原-移植物-糖胺聚糖共聚物（CG共聚物）中的一些已经决定性地将动物和人类皮肤伤口愈合的动力学和机制从收缩和瘢痕合成转向皮肤再生的方向。详细的动物研究表明，当平均孔径和胶原酶降解速率控制在临界限度内时，CG共聚物显示出最大的生物活性。当用最小数量的细胞接种时，这些活性共聚物诱导皮肤再生，包括以正确的解剖学关系合成新的表皮和新的真皮。某些非接种共聚物也诱导周围神经再生。另一种共聚物已经诱导了膝关节半月板的再生。这些共聚物的不寻常的生物活性导致了用于治疗严重烧伤患者皮肤缺损的新型医疗器械的广泛、成功的临床试验。
Simple chemical analogs of extracellular matrices have been synthesized by graft copolymerization of a glycosaminoglycan on to type I collagen. A few of these collagen-graft-glycosaminoglycan copolymers (CG copolymers) have diverted decisively the kinetics and mechanism of skin wound healing in animals and humans away from contraction and scar synthesis, towards the direction of skin regeneration. Detailed animal studies show that CG copolymers show maximum biological activity when the average pore diameter and the degradation rate in collagenase are controlled within critical limits. When seeded with a minimum number of cells these active copolymers induce regeneration of skin, including synthesis of a new epidermis and a new dermis in the correct anatomical relationship. Certain unseeded copolymers have also induced regeneration of peripheral nerve. Another copolymer has induced regeneration of the knee meniscus. The unusual biological activity of these copolymers has led to extensive, successful clinical testing of novel medical devices for the treatment of skin loss with severely burned patients.