The mitogen-activated protein kinase signal transduction pathway.
The mitogen-activated protein kinase signal transduction pathway.
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DOI：
10.1016/s0021-9258(18)82362-6
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发表时间：
1993-07
期刊：
影响因子：
--
通讯作者：
R. Davis
中科院分区：
文献类型：
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作者：
R. Davis
丝裂原活化蛋白激酶（Mitogen-activated protein，MAP）是由多种细胞表面受体启动的信号转导途径中的重要中间体。由这些不同试剂激活的最后一个共同途径是涉及MAP激酶（c-Raf-1（1-3）、Mos（4）和Stell（5））、MAP激酶激酶（6）和MAP激酶的蛋白激酶级联（图1）。MAP激酶活化的一个重要特性是需要蛋白激酶亚结构域VI 11内的Thr和Tyr磷酸化（7，8）。这篇综述的目的是总结在最近的研究中获得的结果，这些研究旨在建立MAP激酶亚型ERK 1和ERK 2激活的意义。
Mitogen-activated protein (MAP)'kinases are important intermediates in signal transduction pathways that are initiated by many types of cell surface receptors. The final common pathway that is activated by these diverse agents is a protein kinase cascade involving MAP kinase kinase kinase (c-Raf-1 (1-3), Mos (4), and Stell (5)), MAPkinase kinase(6), and MAP kinase (Fig. 1). A significant property of MAP kinase activation is the requirement for both Thr and Tyr phosphorylation within the protein kinase subdomain VI11 (7, 8). The purpose of this review is to summarize the results obtained in recent studies that have been designed to establish the significance of the activation of the MAP kinase isoforms ERKl and ERK2.