Channeling antigens to CD8+ T cells.
Channeling antigens to CD8+ T cells.
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将抗原引导至 CD8 T 细胞。
DOI：
10.1126/science.adi5711
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Jakubzick,ClaudiaV
中科院分区：
文献类型：
--
作者：
Rawat,Kavita;Jakubzick,ClaudiaV
细胞毒性CD 8 +T细胞（CTL）可以杀死任何病毒感染的细胞或肿瘤细胞，只要它们在主要组织相容性复合物I类（MHC-I）分子上展示抗原肽。然而，肿瘤细胞或病毒感染的细胞不能以足够刺激的方式呈递抗原，从而也使幼稚的CD 8 +T细胞成为CTL。这是传统树突状细胞（cDC）的作用，它通过捕获MHC-I分子上的外源性细胞相关抗原并将其呈递给幼稚CD 8 +T细胞，同时还提供共刺激，从而桥接先天性和适应性免疫。这个过程称为交叉呈现。尽管交叉呈递对于抗肿瘤和抗病毒免疫以及疫苗设计的重要性，但其机制仍不清楚。在本期的第1258页，Rodríguez-Silvestreet al.report指出，内体穿孔素-2是一种通道形成蛋白，允许将内化的外源性细胞相关抗原释放到交叉呈递cDC的胞质溶胶中。
Cytotoxic CD8+T cells (CTLs) can kill any virus-infected cell or tumor cell, providing they display antigenic peptides on major histocompatibility complex class I (MHC-I) molecules. However, tumor cells or virus-infected cells cannot present antigens in a sufficiently stimulating manner to also prime naïve CD8+T cells to become CTLs. This is the role of conventional dendritic cells (cDCs), which bridge innate and adaptive immunity by capturing exogenous cell-associated antigens on MHC-I molecules and presenting them to naïve CD8+T cells, while also providing costimulation . This process is called cross-presentation . Despite the importance of cross-presentation for antitumor and antiviral immunity and vaccine design, the mechanisms remain unclear. On page 1258 of this issue, Rodríguez-Silvestreet al.report that endosomal perforin-2 is a channel-forming protein that allows the release of internalized exogenous cell-associated antigens to the cytosol of cross-presenting cDCs.
影响因子：
4.3
作者：
H. Sambrook
通讯作者：
H. Sambrook