INCIDENCE AND SEVERITY OF VIRAL-HEPATITIS IN PREGNANCY
INCIDENCE AND SEVERITY OF VIRAL-HEPATITIS IN PREGNANCY
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DOI：
10.1016/0002-9343(81)90758-0
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发表时间：
1981-01-01
影响因子：
5.9
通讯作者：
KHUROO, MI
中科院分区：
文献类型：
--
作者：
KHUROO, MS;TELI, MR;KHUROO, MI
在非甲非乙型肝炎流行期间进行了一项前瞻性现场研究，以确定孕妇、非孕育龄妇女和男性(15-45岁)肝炎的发病率和严重程度。在208名孕妇中，有36人(17.3%)发展为病毒性肝炎，相比之下，3350名未怀孕妇女中有71人(2.1%)，3822名男性中有107人(2.8%)。孕妇的患病率高于2个对照组。妊娠1、2、3周的病毒性肝炎发生率分别为8.8%、19.4%、18.6%。与非妊娠妇女相比，所有3个三孕期的发病率都较高。在8名患有病毒性肝炎的孕妇(22.2%)中，发生了暴发性肝功能衰竭，相比之下，3名男性(2.8%)和未怀孕的女性发生了暴发性肝功能衰竭。妊娠期暴发性肝炎发病率的显著增加预示着妊娠期肝炎的严重程度更高。暴发性肝炎的易感性增加仅在最后三个月观察到。非暴发性病毒性肝炎不会影响妊娠过程或胎儿的健康。致死性重型肝炎中的胎儿丢失是产妇死亡的后果，不能归因于对胎儿或妊娠的直接影响。
A prospective field study was carried out during an epidemic of non-A non-B hepatitis for determining the incidence and severity of hepatitis in pregnant women, nonpregnant women of child bearing age and men (15-45 yr old). In 36 (17.3%) of 208 pregnant women viral hepatitis developed, as compared to 71 (2.1%) of 3350 nonpregnant women and 107 (2.8%) of 3822 men. The incidence of disease in pregnant women was higher than in the 2 control groups. The incidence of viral hepatitis in the 1st, 2nd and 3rd trimesters was 8.8%, 19.4% and 18.6%, respectively. The incidence in all 3 trimesters was higher when compared to that in nonpregnant women. In 8 pregnant women (22.2%) with viral hepatitis, fulminant hepatic failure developed, as compared to its occurrence in 3 men (2.8%) and in no nonpregnant women. This significantly increased incidence of fulminant hepatitis in pregnancy was indicative of a greater severity of hepatitis during pregnancy. Increased susceptibility to fulminant hepatitis was observed exclusively in the last trimester. Nonfulminant viral hepatitis did not influence the course of pregnancy or fetal well-being. Fetal loss in fatal fulminant hepatitis was a consequence of maternal death and could not be ascribed to direct effect on the fetus or pregnancy.