INTERFERENCE COMPETITION AMONG NATURAL FUNGAL COMPETITORS - AN ANTIFUNGAL METABOLITE FROM THE COPROPHILOUS FUNGUS PREUSSIA-FLEISCHHAKII
INTERFERENCE COMPETITION AMONG NATURAL FUNGAL COMPETITORS - AN ANTIFUNGAL METABOLITE FROM THE COPROPHILOUS FUNGUS PREUSSIA-FLEISCHHAKII
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DOI：
10.1021/np50059a011
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发表时间：
1988-09-01
影响因子：
5.1
通讯作者：
GLOER, JB
中科院分区：
文献类型：
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作者：
WEBER, HA;GLOER, JB
化合物1（2,3′-二羟基-4-甲氧基-5′，6-二甲基二苯醚）是兔粪真菌寄主Preussia fleischhakii与早期连续寄主Ascobolus furfuracens和Sordaria fimicola干扰竞争的主要病原体。化合物1通过硅胶层析和反相高效液相色谱从fleischhakii液体培养物的乙酸乙酯提取物中分离得到，并通过1H-nmr、13C-nmr和ms数据进行鉴定。采用体外生物活性测定法对糠秕霉属真菌和金黄色葡萄球菌进行抑菌活性测定。这些结果表明，在相对未开发的天然真菌群落中观察到的干扰竞争研究可能是发现抗真菌药物的有价值的、生态合理的方法。
Compound 1 (2,3''-dihydroxy-4-methoxy-5'',6-dimethyldiphenyl ether) has been established as the major causative agent of interference competition between Preussia fleischhakii, a fungal colonist of rabbit dung, and two early successional dung colonists, Ascobolus furfuracens and Sordaria fimicola. Compound I was isolated from EtOAc extracts of liquid cultures of P. fleischhakii by Si gel chromatography and reversed-phase hplc and was identified by analysis of 1H-nmr, 13C-nmr, and ms data. The isolation process was guided by in vitro bioassays for antifungal activity against A. furfuraceus and S. fimicola. These results suggest that studies of interference competition observed in relatively unexplored natural fungal communities may be a valuable, ecologically rational approach to the discovery of antifungal agents.