Simultaneous expression of brain-derived neurotrophic factor and neurotrophin-3 in Cajal-Retzius, subplate and ventricular progenitor cells during early development stages of the rat cerebral cortex
Simultaneous expression of brain-derived neurotrophic factor and neurotrophin-3 in Cajal-Retzius, subplate and ventricular progenitor cells during early development stages of the rat cerebral cortex
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DOI：
10.1016/s0306-4522(97)00505-8
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发表时间：
1998-05-01
期刊：
影响因子：
3.3
通讯作者：
Furukawa, S
中科院分区：
文献类型：
--
作者：
Fukumitsu, H;Furukawa, Y;Furukawa, S
为了确定神经营养因子在神经发生过程中的产生部位和作用靶点，我们研究了神经营养因子及其酪氨酸激酶受体在大鼠胚胎大脑皮层中的免疫反应性。两套配体-受体系统，脑源性神经营养因子/TrkB和神经营养因子-3/TrkC，同时表达在Cajal-Retzius，基板神经元和心室多能干细胞在胚胎第13和15天。脑室内注射脑源性神经营养因子或神经营养因子-3可显著调节胚胎第20天皮层板细胞微管相关蛋白II和/或Hu蛋白的表达。这些观察结果表明脑源性神经营养因子和/或神经营养因子-3的自分泌和/或局部旁分泌作用参与了大脑皮层的形成。(C)1998年IBRO。爱思唯尔科技有限公司出版
To identify production sites and action targets of neurotrophins during neurogenesis, we investigated immunoreactivities of neurotrophins and their tyrosine kinase receptors in the cerebral cortex of rat embryos. Two sets of ligand-receptor systems, brain-derived neurotrophic factor/TrkB and neurotrophin-3/TrkC, were expressed simultaneously in Cajal-Retzius, subplate neurons and ventricular multipotent stem cells at embryonic days 13 and 15. Intraventricular administration of brain-derived neurotrophic factor or neurotrophin-3 at embryonic day 16 markedly modulated microtubule-associated protein II and/or Hu protein expression in different ways in the cortical plate cells by embryonic day 20.These observations indicate the involvement of autocrine and/or local paracrine action of brain-derived neurotrophic factor and/or neurotrophin-3 during formation of the cerebral cortex. (C) 1998 IBRO. Published by Elsevier Science Ltd.