Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts.
Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts.
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DOI：
10.1016/j.jhep.2015.03.032
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发表时间：
2015-08
影响因子：
25.7
通讯作者：
McKeown NM
中科院分区：
文献类型：
--
作者：
Ma J;Fox CS;Jacques PF;Speliotes EK;Hoffmann U;Smith CE;Saltzman E;McKeown NM
非酒精性脂肪性肝病影响了大约30%的美国成年人，但含糖饮料和无糖苏打水对这些疾病的作用尚不清楚。我们在Framingham子代和第三代队列的参与者中研究了摄入含糖饮料或无糖苏打水与脂肪肝疾病之间的横截面关联。在2634名参与者中，使用计算机断层扫描产生的肝脏衰减测量来定义脂肪肝。对5908名参与者进行了丙氨酸转氨酶浓度的测定，丙氨酸转氨酶是脂肪肝的一个粗略标志。使用食物频率调查问卷估计含糖饮料和无糖苏打水的摄入量。参与者被归类为非消费者或含糖饮料或无糖汽水的消费者(3类：1份/月至1份/周，1份/周至1份/天，以及⩾1份/天)。在调整了年龄、性别、吸烟状况、Framingham队列、能量摄入、酒精、膳食纤维、脂肪(%能量)、蛋白质(%能量)、无糖汽水摄入量和体重指数后，在所有含糖饮料消费类别中，患脂肪肝的优势比分别为1，1.16(0.88，1.54)，1.32(0.93，1.86)和1.61(1.04，2.49)(p趋势=0.04)。含糖饮料的摄入量与丙氨酸转氨酶水平也呈正相关(p趋势=0.007)。我们没有观察到无糖汽水摄入量与脂肪肝指标之间的显著关联。总而言之，我们观察到，经常饮用含糖饮料会增加患脂肪肝的风险，特别是在超重和肥胖的人中，而无糖苏打水的摄入量与脂肪肝的指标无关。
Non-alcoholic fatty liver disease affects ~30% of US adults, yet the role of sugar-sweetened beverages and diet soda on these diseases remains unknown. We examined the cross-sectional association between intake of sugar-sweetened beverages or diet soda and fatty liver disease in participants of the Framingham Offspring and Third Generation cohorts. Fatty liver disease was defined using liver attenuation measurements generated from computed tomography in 2634 participants. Alanine transaminase concentration, a crude marker of fatty liver disease, was measured in 5908 participants. Sugar-sweetened beverage and diet soda intake were estimated using a food frequency questionnaire. Participants were categorized as either non-consumers or consumers (3 categories: 1 serving/month to <1 serving/week, 1 serving/week to <1 serving/-day, and ⩾1 serving/day) of sugar-sweetened beverages or diet soda. After adjustment for age, sex, smoking status, Framingham cohort, energy intake, alcohol, dietary fiber, fat (% energy), protein (% energy), diet soda intake, and body mass index, the odds ratios of fatty liver disease were 1, 1.16 (0.88, 1.54), 1.32 (0.93, 1.86), and 1.61 (1.04, 2.49) across sugar-sweetened beverage consumption categories (p trend = 0.04). Sugar-sweetened beverage consumption was also positively associated with alanine transaminase levels (p trend = 0.007). We observed no significant association between diet soda intake and measures of fatty liver disease. In conclusion, we observed that regular sugar-sweetened beverage consumption was associated with greater risk of fatty liver disease, particularly in overweight and obese individuals, whereas diet soda intake was not associated with measures of fatty liver disease.