Effects of acute diarrhea on linear growth in Peruvian children
Effects of acute diarrhea on linear growth in Peruvian children
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DOI：
10.1093/aje/kwf179
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发表时间：
2003-01-15
影响因子：
5
通讯作者：
Black, RE
中科院分区：
文献类型：
--
作者：
Checkley, W;Epstein, LD;Black, RE
儿童期线性生长迟缓是发展中国家成年人身材矮小和能力受损的决定因素。为了研究儿童时期腹泻对身高的影响，作者对224名秘鲁儿童的出生队列进行了35个月的随访，记录了每日腹泻和每月人体测量。本研究于1995年4月至1998年12月进行。在24个月大时，研究儿童比美国国家卫生统计中心/世界卫生组织的生长参考矮2.5厘米。在出生后的前24个月内，2.3%的腹泻患病率解释了这种生长缺陷的2-27%。在腹泻对身高的影响变得明显之前有2个月的延迟。身高不足与肥胖患病率成正比。例如，在最初的24个月里，10%的时间患有腹泻的儿童比从未患过腹泻的儿童矮1.5厘米。此外，腹泻对身高的不良影响因年龄而异。在出生后的前6个月内腹泻会导致长期的身高不足，这可能是永久性的。相比之下，6个月龄后的腹泻表现出短暂的影响。研究结果表明，腹泻控制，特别是在生命的前6个月，可能会改善秘鲁儿童的线性增长。
Linear growth retardation during childhood is a determinant of short stature and impaired capacities in adults of developing countries. To study the effect of diarrhea on height during childhood, the authors followed a birth cohort of 224 Peruvian children for 35 months with records of daily diarrhea and monthly anthropometry. This study was conducted from April 1995 to December 1998. At 24 months of age, study children were 2.5 cm shorter than the US National Center for Health Statistics/World Health Organization growth reference. A diarrheal prevalence of 2.3% in the first 24 months of life explained 2-27% of this growth deficit. There was a 2-month delay before the effects of diarrhea on height became manifest. Height deficits were proportional to diarrheal prevalence. For example, children ill with diarrhea 10% of the time during the first 24 months were 1.5 cm shorter than children who never had diarrhea. In addition, the adverse effects of diarrhea on height varied by age. Diarrhea during the first 6 months of life resulted in long-term height deficits that were likely to be permanent. In contrast, diarrhea after 6 months of age showed transient effects. Study results indicate that diarrhea control, especially during the first 6 months of life, is likely to improve linear growth in Peruvian children.