The prevalence of intrinsic subtypes and prognosis in breast cancer patients of different races
The prevalence of intrinsic subtypes and prognosis in breast cancer patients of different races
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DOI：
10.1016/j.breast.2007.07.017
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发表时间：
2007-12-01
期刊：
影响因子：
3.9
通讯作者：
Nakashima, Kazutaka
中科院分区：
文献类型：
--
作者：
Kurebayashi, Junichi;Moriya, Takuya;Nakashima, Kazutaka
最近的一份报告显示，基底样乳腺肿瘤（雌激素受体[ER]阴性，孕激素受体[PR]阴性，人表皮生长因子受体[HER] 2阴性，细胞角蛋白5/6阳性和/或her1阳性）的高发率可能导致非洲裔美国女性乳腺癌预后不良。据报道，日本女性乳腺癌患者的存活率明显高于美国其他种族的患者。这些发现表明，日本女性的乳腺癌具有有利的生物学特征。为了澄清这一假设，我们进行了一项队列研究，调查793名日本患者内在亚型的患病率和每种亚型的预后。本研究显示，在日本患者中具有侵袭性生物学特征的基底样乳腺肿瘤的患病率非常低（仅8%）。生存分析显示，基底样肿瘤患者的预后明显差于具有良好生物学特性的腔内a肿瘤患者（ER-和/或pr -阳性，her2阴性）。这些发现支持了一种假设，即日本女性的乳腺癌比其他种族的女性具有更有利的生物学特征和更好的预后。综上所述，基底样乳腺肿瘤的患病率会影响不同种族乳腺癌患者的预后。在多种族/国际临床研究中分析生存数据时，应考虑固有亚型的流行。(C) 2007 Elsevier Ltd.版权所有。
A recent report indicated that a high prevalence of basal-like breast tumors (estrogen receptor [ER]-negative, progesterone receptor [PR]-negative, human epidermal growth factor receptor [HER] 2-negative, and cytokeratin 5/6-positive and/or HER1-positive) could contribute to a poor prognosis in African American women with breast cancer. It has been reported that Japanese women with breast cancer have a significantly better survival rate than other races in the USA. These findings suggest that breast cancers in Japanese women have favorable biological characteristics. To clarify this hypothesis, we conducted a cohort study to investigate the prevalence of intrinsic subtypes and prognosis for each subtype in 793 Japanese patients. This study revealed a very low prevalence (only 8%) of basal-like breast tumors with aggressive biological characteristics in Japanese patients. Survival analysis showed a significantly poorer prognosis in patients with basal-like tumors than in those with luminal A tumors (ER- and/or PR-positive, and HER2-negative) with favorable biological characteristics. These findings support the hypothesis that breast cancers in Japanese women have more favorable biological characteristics and a better prognosis than those in other races. In conclusion, the prevalence of basal-like breast tumors could influence the prognosis of breast cancer patients of different races. The prevalence of intrinsic subtypes should be taken into account when analyzing survival data in a multi-racial/international clinical study. (C) 2007 Elsevier Ltd. All rights reserved.