Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans.
Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans.
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DOI：
10.1093/neucas/3.4.267-c
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发表时间：
1997-08
期刊：
影响因子：
56.9
通讯作者：
A. Bechara;D. Tranel;H. Damasio;R. Adolphs;C. Rockland;A. Damasio
中科院分区：
文献类型：
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作者：
A. Bechara;D. Tranel;H. Damasio;R. Adolphs;C. Rockland;A. Damasio
选择性双侧杏仁核损伤的患者没有获得条件自主反应的视觉或听觉刺激，但获得的陈述性事实的视觉或听觉刺激与非条件刺激配对。相比之下，海马体选择性双侧损伤的患者未能获得事实，但确实获得了条件反射。最后，一个杏仁核和海马结构都受损的病人既没有条件反射，也没有事实。这些发现表明，相对于人类杏仁核和海马体，条件反射和陈述性知识存在双重分离。
A patient with selective bilateral damage to the amygdala did not acquire conditioned autonomic responses to visual or auditory stimuli but did acquire the declarative facts about which visual or auditory stimuli were paired with the unconditioned stimulus. By contrast, a patient with selective bilateral damage to the hippocampus failed to acquire the facts but did acquire the conditioning. Finally, a patient with bilateral damage to both amygdala and hippocampal formation acquired neither the conditioning nor the facts. These findings demonstrate a double dissociation of conditioning and declarative knowledge relative to the human amygdala and hippocampus.