Cord blood α-fetoprotein concentrations in term newborns of smoking mothers
Cord blood α-fetoprotein concentrations in term newborns of smoking mothers
复制标题
DOI：
10.1007/s004310051152
复制
发表时间：
1999-07-01
影响因子：
3.6
通讯作者：
Kourounis, G
中科院分区：
文献类型：
--
作者：
Beratis, NG;Varvarigou, A;Kourounis, G
为了研究烟草烟雾对胎儿的毒性作用，我们测量了脐带血中甲胎蛋白（AFP）（个体发育早期的主要血清蛋白）和促红细胞生成素（EPO）的浓度，作为胎儿慢性缺氧的SN指数。共有 103 名连续入组的吸烟母亲的足月新生儿和 103 名不吸烟父母的足月婴儿进行了研究。每天吸烟 1-50、5-50 和 10-50 支香烟的母亲的新生儿 AFP 浓度平均值+/-SD 分别为 86.4 +/- 88.9、96.3 +/- 91.9 和 118.7 +/- 103.7 ng/ml。所有三组与对照新生儿 (57.7 +/- 37.2) 的差异均显着。每天吸烟 1-50 (53.9 +/- 64.6 mU/ml) 和 5-50 (56.3 +/- 68.5) 支香烟的母亲新生儿中 EPO 浓度显着高于对照新生儿 (29.5 +/- 16.1)。在吸烟母亲的新生儿中，AFP 浓度与每天吸烟数量呈显着正相关，而 AFP 与出生体重或身长呈负相关。 AFP和EPO浓度之间以及EPO与出生体重、长度或每天吸烟数量之间没有相关性。 结论 促红细胞生成素与出生体重或长度之间不存在相关性，而cc-胎蛋白与这些人体测量参数之间呈负相关，提示母亲吸烟引起的宫内生长迟缓不是由于组织缺氧，而是生长迟缓和甲胎蛋白升高是由直接或间接的毒性作用引起的。烟草烟雾中存在的因素。
To investigate the toxic effect of tobacco smoke on the fetus, we measured in cord blood the concentrations of alpha-fetoprotein (AFP), the principal serum protein in early ontogenic development, and erythropoietin (EPO), as sn index of chronic fetal hypoxia. A total of 103 consecutively enrolled term newborns of smoking mothers and 103 term infants of nonsmoking parents were studied. The mean +/- SD AFP concentrations in the newborns of the mothers who smoked 1-50, 5-50, and 10-50 cigarettes/day were 86.4 +/- 88.9, 96.3 +/- 91.9 and 118.7 +/- 103.7 ng/ml, respectively. The difference of all three groups from the control neonates (57.7 +/- 37.2) was significant. The EPO concentrations in the newborns of the mothers who smoked 1-50 (53.9 +/- 64.6 mU/ml) and 5-50 (56.3 +/- 68.5) cigarettes/day were significantly greater than in the control neonates (29.5 +/- 16.1). In the newborns of the smoking mothers there was a significant positive correlation between AFP concentrations and number of cigarettes smoked per day, and a negative correlation between AFP and birth weight or length. There was no correlation between AFP and EPO concentrations, as well as between EPO and birth weight, length or number of cigarettes smoked per day.Conclusion The absence of a correlation between erythropoietin and birth weight or length and the negative correlations between cc-fetoprotein and these anthropometric parameters suggest that the intra-uterine growth retardation caused by maternal smoking is not due to tissue hypoxia, but that both growth retardation and elevated alpha-fetoprotein result from the direct or indirect toxic effect of a factor(s) present in tobacco smoke.