Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities
Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities
复制标题
DOI：
10.1016/j.neurobiolaging.2018.06.012
复制
发表时间：
2018-10-01
影响因子：
4.2
通讯作者：
Henson, Rik N.
中科院分区：
文献类型：
--
作者：
Chan, Dennis;Shafto, Meredith;Henson, Rik N.
这项研究检验了中年智力、身体和社交活动有助于认知储备 (CR) 的假设。研究人员对来自剑桥衰老和神经科学中心 (www.cam-can.com) 的 205 名年龄在 66-88 岁之间的个体（其中 196 名进行了磁共振成像）进行了研究，分别以液体智商和总灰质体积来衡量认知能力和结构性大脑健康状况。使用一生经历问卷来衡量中年活动（MA）。多变量线性回归发现，MA 对晚年认知能力做出了独特的贡献，与教育、职业和晚年活动无关。至关重要的是，MA 调节了晚年认知能力与大脑健康之间的关系，MA 较高的人的认知能力对其大脑结构的依赖性较小，这与 CR 的概念一致。总之，MA 对 CR 的贡献是独特的。这些活动的可修改性对旨在预防痴呆症的公共卫生举措具有影响。 (C) 2018 Elsevier Inc. 保留所有权利。
This study tested the hypothesis that mid-life intellectual, physical, and social activities contribute to cognitive reserve (CR). Two hundred five individuals (196 with magnetic resonance imaging) aged 66-88 years from the Cambridge Centre for Ageing and Neuroscience (www.cam-can.com) were studied, with cognitive ability and structural brain health measured as fluid IQ and total gray matter volume, respectively. Mid-life activities (MAs) were measured using the Lifetime of Experiences Questionnaire. Multivariable linear regression found that MAs made a unique contribution to late-life cognitive ability independent of education, occupation, and late-life activities. Crucially, MAs moderated the relationship between late-life cognitive ability and brain health, with the cognitive ability of people with higher MA less dependent on their brain structure, consistent with the concept of CR. In conclusion, MAs contribute uniquely to CR. The modifiability of these activities has implications for public health initiatives aimed at dementia prevention. (C) 2018 Elsevier Inc. All rights reserved.