Acute cognitive effects of nonconvulsive difficult-to-detect epileptic seizures and epileptiform electroencephalographic discharges
Acute cognitive effects of nonconvulsive difficult-to-detect epileptic seizures and epileptiform electroencephalographic discharges
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DOI：
10.2310/7010.2001.6990
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发表时间：
2001-02-01
影响因子：
1.9
通讯作者：
Diepman, L
中科院分区：
文献类型：
--
作者：
Aldenkamp, AP;Arends, J;Diepman, L
本研究比较了儿童短期非惊厥性发作与发作间期癫痫样脑电图（EEG）放电的急性认知效应。本研究是一项前瞻性、标准化、非随机、开放性临床比较研究。符合条件的患者包括（a）癫痫发作不明确和认知能力波动和（B）最近EEG中频繁的癫痫样EEG放电。所有儿童均接受EEG/视频（Brainlab（R））评估，同时进行计算机神经心理测试（FePsy（R）），评估运动速度/警觉性，精神速度/注意力和记忆功能。纳入11例在认知测试期间出现短暂非惊厥性癫痫发作的患者，并与11例在认知测试期间出现发作间期癫痫样EEG放电但无癫痫发作的匹配患者进行比较。两组患者均再次确诊为癫痫。比较两组的认知表现。统计分析显示，癫痫发作次数（在认知测试中）与警觉性受损之间以及发作期持续时间与记忆受损之间存在显著相关性。发作间期癫痫样。EEG放电对认知功能没有额外的独立影响。结果表明癫痫发作的累积认知效应，并说明频繁的癫痫发作，即使这些发作持续时间很短，并且具有微妙的神经病学，也会对日常生活产生重大影响，并可能导致状态依赖性学习障碍。警觉性和短期记忆似乎是最容易受到癫痫发作急性影响的功能。
This study compares the acute cognitive effects of short nonconvulsive seizures with the effects of interictal epileptiform electroencephalographic (EEG) discharges in children. The study is a prospective, standardized, nonrandomized, and open clinical comparative study. Eligible patients were included when they had (a) unclear seizures and fluctuations in cognitive performance and (b) frequent epileptiform EEG discharges in a recent EEG. All children were assessed with EEG/video (Brainlab (R)) simultaneously with computerized neuropsychologic testing (FePsy (R)) assessing motor speed/alertness, mental speed/attention, and memory function. Eleven patients with short nonconvulsive seizures during cognitive testing were included and compared with 11 matched patients with interictal epileptiform EEG discharges during cognitive testing but without seizures. Patients included in both groups had a reconfirmed diagnosis of epilepsy. Cognitive performance for both groups was compared. Statistical analysis showed significant correlations beween the number of seizures (during cognitive testing) and impaired alertness and between the duration of the ictal period and memory impairment. Interictal epileptiform. EEG discharges do not have an additional independent effect on cognitive function. The results demonstrate the accumulating cognitive effect of seizures and illustrate that frequent seizures, even when these are short in duration and with subtle symptomatology, can have a substantial impact on daily life and can lead to state-dependent learning impairment. Alertness and short-term memory appeared to be the functions that are most vulnerable for the acute effects of seizures.