The common functional polymorphism-50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes
The common functional polymorphism-50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes
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DOI：
10.1097/hjh.0b013e328333097e
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发表时间：
2010-02-01
影响因子：
4.9
通讯作者：
Melander, Olle
中科院分区：
文献类型：
--
作者：
Fava, Cristiano;Montagnana, Martina;Melander, Olle
背景 CYP2J2 负责产生 5,6 8,9 11,12 和 14,15-环氧二十碳三烯酸、血管扩张剂和抗炎物质。它在人类心脏中大量表达，也存在于肾脏和脉管系统中。常见多态性 CYP2J2 -50G>T、rs890293 的携带者推测，通过干扰转录因子的结合位点，降低了心脏中 CYP2J2 mRNA 的表达水平，从而降低了体内 CYP2J2 环氧化酶代谢物的循环水平。方法对“马尔默饮食与癌症”研究心血管队列的 5740 名参与者进行了 CYP2J2 多态性基因分型。随访 10 年期间监测心血管事件（冠状动脉事件，n = 261；缺血性中风，n = 185）的发生率。 结果 在整个人群中，多态性对血压和高血压患病率没有影响，并且未发现多态性与性别、年龄或体重指数之间存在相互作用。在调整主要心血管危险因素之前和之后，不同基因型携带者发生缺血性卒中和冠状动脉事件的风险比没有显着差异。结论我们的数据不支持CYP2J2 -50G>T变异在确定血压水平和发生缺血性事件中的主要作用。需要其他研究来阐明同一基因中的其他多态性是否可能在血压稳态或心血管事件发生率中发挥作用。 J Hypertens 28：294-299 (C) 2010 Wolters Kluwer Health |利平科特·威廉姆斯和威尔金斯。
Background CYP2J2 is responsible for the production of 5,6 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. It is abundantly expressed in human heart and also present in kidney and vasculature. Carriers of a common polymorphism, the CYP2J2 -50G>T, rs890293, have reduced expression of CYP2J2 mRNA level in the heart putatively through the interference with a binding site for a transcription factor with consequently reduced circulating levels of CYP2J2 epoxygenase metabolites in vivo.Aim The aim of the present study was to evaluate the effect of this functional polymorphism on blood pressure (BP) levels, hypertension prevalence, and risk of incident cardiovascular events in middle-aged Swedes.Methods The CYP2J2 polymorphism was genotyped in 5740 participants of the cardiovascular cohort of the 'Malmo Diet and Cancer' study. The incidence of cardiovascular events (coronary events, n = 261; ischemic stroke, n = 185) was monitored over 10 years of follow-up.Results In the whole population the polymorphism had no effect on BP and hypertension prevalence and no interaction was found between the polymorphism and sex, age or body mass index. Before and after adjustment for major cardiovascular risk factors, the hazard ratio for incident ischemic stroke and coronary events was not significantly different in carriers of different genotypes.Conclusions Our data do not support a major role for the CYP2J2 -50G>T variant in determining BP level and incident ischemic events. Other studies are needed to elucidate if other polymorphisms in the same gene could have a role in BP homeostasis or incidence of cardiovascular events. J Hypertens 28: 294-299 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.