Toolboxes for plant systems biology research
Toolboxes for plant systems biology research
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植物系统生物学研究工具箱
DOI：
10.1016/j.copbio.2022.102692
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发表时间：
2022
影响因子：
7.7
通讯作者：
Cheung, Lily S
中科院分区：
文献类型：
--
作者：
Park, Jihyun;Demirer, Gozde S;Cheung, Lily S
“系统”和“合成生物学”这两个术语经常一起使用，大多数科学家都在这两个领域之间跨越，而不是坚持单一的一面。通常，科学家们也希望了解一个系统，以告知基因电路的设计，从而赋予它新的功能。然而，这并不一定是研究的进展，因为合成结构可以帮助提高我们对系统的理解。在这里，我们回顾合成生物学工具包，有可能克服多效性效应，补偿机制，和冗余的植物。结合组学技术，这些工具可以揭示植物生长和发育的新见解，鉴于气候变化对作物生产力的影响，这一目标已经变得更加紧迫。
The terms ‘systems’ and ‘synthetic biology’ are often used together, with most scientists striding between the two fields rather than adhering to a single side. Often too, scientists want to understand a system to inform the design of gene circuits that could endow it with new functions. However, this does not need to be the progression of research, as synthetic constructs can help improve our understanding of a system. Here, we review synthetic biology tool kits with the potential to overcome pleiotropic effects, compensatory mechanisms, and redundancy in plants. Combined with -omics techniques, these tools could reveal novel insights on plant growth and development, an aim that has gained renewed urgency given the impact of climate change on crop productivity.