Utility of patch testing in patients with hypersensitivity syndromes associated with abacavir
Utility of patch testing in patients with hypersensitivity syndromes associated with abacavir
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DOI：
10.1097/00002030-200211080-00017
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发表时间：
2002-11-08
期刊：
影响因子：
3.8
通讯作者：
Shear, NH
中科院分区：
文献类型：
--
作者：
Phillips, EJ;Sullivan, JR;Shear, NH
诊断性测试有助于消除疑似超敏患者在阿巴卡韦满剂量再激发后的相关发病率和死亡率。我们描述了7名与阿巴卡韦过敏症状相容的患者，他们的斑贴试验呈阳性。急性预期确诊的皮疹患者(n=3)的皮肤活检免疫组织化学与阳性斑贴患者(n=7)的皮肤活检免疫组织化学结果一致，表明其病理生理过程相同。在贴片测试期间，患者没有出现全身症状或体征。
A diagnostic test would be useful to help eliminate the associated morbidity and mortality after full-dose rechallenge with abacavir in patients with suspected hypersensitivity. We describe seven patients with syndromes compatible with abacavir hypersensitivity who had positive patch tests. Immunohistochemistry on skin biopsies from the acute prospectively identified patients with rash (n = 3) matched those from positive-patch patients (n = 7), suggesting an identical pathophysiological process. No patients developed systemic symptoms or signs during patch testing.