Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee
Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee
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DOI：
10.1097/00001648-199903000-00013
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发表时间：
1999-03-01
期刊：
影响因子：
5.4
通讯作者：
Walker, AM
中科院分区：
文献类型：
--
作者：
Oliveria, SA;Felson, DT;Walker, AM
研究表明，肥胖和膝关节骨关节炎之间存在正相关。然而，评估手或髋关节骨关节炎和体重的研究评估了X线骨关节炎或横断面骨关节炎，或两者兼而有之，这些结果不一致。我们评估了134对配对的病例对照妇女的体重、体重指数和偶发症状性骨关节炎之间的关系，这些妇女是雌激素替代治疗和骨关节炎病例对照研究的一部分。我们确定了在1990年1月1日至1993年12月31日期间参加健康计划的20-89岁妇女的手、髋和膝关节的偶发症状性骨关节炎病例。对于每一个病例，我们选择了一名对照妇女，她的出生日期与病例最接近。对病历进行了审查，以获得疾病发作前的体重和身高信息。在控制了雌激素使用、吸烟状况、身高和医疗保健使用后，我们发现体重是手、髋和膝关节骨关节炎发生的预测因素。体重上三分位数的女性与体重下三分位数的女性相比，比值比范围为3.0至10.5。体重指数也有类似的关联。我们的研究结果表明，肥胖与所有研究关节的偶发性骨关节炎的发生有关。
Studies have shown a positive association between obesity and knee osteoarthritis. Studies evaluating hand or hip osteoarthritis and weight, however, have assessed x-ray osteoarthritis or been cross-sectional, or both, and results of these have been inconsistent. We assessed the association between body weight, body mass index, and incident symptomatic osteoarthritis in 134 matched case-control pairs of women who were part of a case-control study on estrogen replacement therapy and osteoarthritis. We identified incident symptomatic osteo arthritis cases of the hand, hip, and knee in women ages 20-89 years who were members of a health plan between January 1, 1990 and December 31, 1993. For each case we selected a control woman who was matched by closest date of birth to the case. Medical records were reviewed to obtain weight and height information for the period before disease onset. After controlling for estrogen use, smoking status, height, and health care use, we found that body weight was a predictor of incident osteoarthritis of the hand, hip, and knee. Odds ratios ranged from 3.0 to 10.5 for women in the upper tertiles of weight compared with women in the lowest tertile. Similar associations were observed for body mass index. Our results suggest that obesity is associated with the development of incident osteoarthritis at all joints studied.