Intralaminar stimulation of the inferior colliculus facilitates frequency-specific activation in the auditory cortex
Intralaminar stimulation of the inferior colliculus facilitates frequency-specific activation in the auditory cortex
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下丘的层内刺激促进听觉皮层的频率特异性激活
DOI：
10.1088/1741-2560/10/4/046008
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发表时间：
2013
影响因子：
4
通讯作者：
A. Paolini
中科院分区：
文献类型：
--
作者：
B. Allitt;C. Benjaminsen;S. Morgan;A. Paolini
客观的。听觉中脑植入物 (AMI) 为开放式语音感知提供了不充分的频率辨别能力。可以利用中脑音位层流的 AMI 可能能够更好地提供特定频率的感知并提高性能。需要确定最能引发特定频率活动的刺激策略。这项研究检查了听觉皮层 (AC) 区域之间的特征频率 (CF) 关系，以响应下丘 (IC) 的刺激区域，比较单极和层内双极电刺激。方法。使用 IC 中的多通道微电极阵列进行电刺激，用于在麻醉的雄性连帽 Wistar 大鼠中引发 AC 反应。使用 3 kHz 以内的 CF（CF 对齐）和未对齐的 CF 的 AC 区域的活动率来评估响应的频率特异性。主要结果。单极和双极 IC 刺激都会导致 AC 中 CF 对齐的神经活动。改变 IC 中的刺激电极和参考电极之间的距离会导致阈值和动态范围发生变化，间距为 400 µm 的双极刺激可产生最低的 AC 阈值和最宽的动态范围。饱和时，当电极间距为 400 µm 或更小时，双极刺激在 CF 对齐区域的 AC 中引起的平均尖峰计数明显高于 CF 未对齐区域。使用 400 µm 或更小的电极间距的双极刺激也比单极刺激在 CF 对齐和 CF 未对齐区域中引起了更高的 AC 诱发活动率。当电极间隔 600 µm 时，没有观察到比单极刺激有任何好处。此外，当刺激和参考位点相距 200 µm 时，IC 外部皮层的单极刺激比双极刺激产生更多的局部频率响应。意义。这些发现对 AMI 的未来发展具有影响，因为双极刺激策略可能会提高植入物使用者区分频率的能力。
Objective. Auditory midbrain implants (AMI) provide inadequate frequency discrimination for open set speech perception. AMIs that can take advantage of the tonotopic laminar of the midbrain may be able to better deliver frequency specific perception and lead to enhanced performance. Stimulation strategies that best elicit frequency specific activity need to be identified. This research examined the characteristic frequency (CF) relationship between regions of the auditory cortex (AC), in response to stimulated regions of the inferior colliculus (IC), comparing monopolar, and intralaminar bipolar electrical stimulation. Approach. Electrical stimulation using multi-channel micro-electrode arrays in the IC was used to elicit AC responses in anaesthetized male hooded Wistar rats. The rate of activity in AC regions with CFs within 3 kHz (CF-aligned) and unaligned CFs was used to assess the frequency specificity of responses. Main results. Both monopolar and bipolar IC stimulation led to CF-aligned neural activity in the AC. Altering the distance between the stimulation and reference electrodes in the IC led to changes in both threshold and dynamic range, with bipolar stimulation with 400 µm spacing evoking the lowest AC threshold and widest dynamic range. At saturation, bipolar stimulation elicited a significantly higher mean spike count in the AC at CF-aligned areas than at CF-unaligned areas when electrode spacing was 400 µm or less. Bipolar stimulation using electrode spacing of 400 µm or less also elicited a higher rate of elicited activity in the AC in both CF-aligned and CF-unaligned regions than monopolar stimulation. When electrodes were spaced 600 µm apart no benefit over monopolar stimulation was observed. Furthermore, monopolar stimulation of the external cortex of the IC resulted in more localized frequency responses than bipolar stimulation when stimulation and reference sites were 200 µm apart. Significance. These findings have implications for the future development of AMI, as a bipolar stimulation strategy may improve the ability of implant users to discriminate between frequencies.
使用科利耳公司“20 2”植入物的患者表现：双极激活与单极激活。
DOI：
--
发表时间：
1996
期刊：
The American journal of otology.
影响因子：
--
作者：
Zwolan,TA;Kileny,PR;Ashbaugh,C;Telian,SA
通讯作者：
Telian,SA
影响因子：
2.5
作者：
Bierer, JA;Middlebrooks, JC
通讯作者：
Middlebrooks, JC