Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related Mortality
Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related Mortality
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DOI：
10.1371/journal.pone.0163728
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发表时间：
2016-09-29
期刊：
影响因子：
3.7
通讯作者：
John, Chandy C.
中科院分区：
文献类型：
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作者：
Brand, Nathan R.;Opoka, Robert O.;John, Chandy C.
乳酸酸中毒（LA）是重症疟疾死亡率的标志物，但导致不同类型重症疟疾中LA的机制以及LA相关死亡率在不同类型重症疟疾中的差异程度尚未得到很好的描述。我们评估了乌干达坎帕拉Mulago医院收治的患有脑型疟疾（CM，n = 193）或严重疟疾性贫血（SMA，n = 216）的儿童中LA的频率。将LA与死亡率和寄生虫生物量和隔离措施（恶性疟原虫富组氨酸蛋白-2（PfHRP 2）浓度，血小板计数）以及全身组织氧输送措施（血红蛋白水平）进行比较。SMA患儿LA发生率高于CM患儿（SMA 47.7%，CM 34.2%，P = 0.006），但CM患儿死亡率（13.0%）高于SMA（0.5%，P
Lactic acidosis (LA) is a marker for mortality in severe malaria, but the mechanisms that lead to LA in the different types of severe malaria and the extent to which LA-associated mortality differs by type of severe malaria are not well described. We assessed the frequency of LA in children admitted to Mulago Hospital, Kampala, Uganda with cerebral malaria (CM, n = 193) or severe malarial anemia (SMA, n = 216). LA was compared to mortality and measures of parasite biomass and sequestration (P. falciparum histidine-rich protein-2 (PfHRP2) concentration, platelet count), and to a measure of systemic tissue oxygen delivery (hemoglobin level). LA was more frequent in children with SMA than CM (SMA, 47.7%, CM, 34.2%, P = 0.006), but mortality was higher in children with CM (13.0%) than SMA (0.5%, P