Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder
Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder
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DOI：
10.1016/j.jad.2008.12.001
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发表时间：
2009-08-01
影响因子：
6.6
通讯作者：
Kapczinski, Flavio
中科院分区：
文献类型：
--
作者：
Brietzke, Elisa;Stertz, Laura;Kapczinski, Flavio
背景：双相情感障碍的神经生物学尚未完全了解。细胞因子作为与免疫、神经内分泌系统以及情绪、能量和活动控制相关的特定通路相互作用的潜在介导剂，已受到越来越多的关注。先前的报道表明躁狂和双相抑郁与促炎状态有关。然而，他们没有比较细胞因子水平在所有阶段的双相disorder.Methods：61双相患者被招募的血清细胞因子水平进行评估。其中，14人处于心境正常状态，23人和24人分别处于躁狂和抑郁发作状态。健康对照组包括25名健康志愿者。结果：躁狂发作时，促炎细胞因子IL-2、IL-4、IL-6均较健康对照组升高，而IL-10、IL-6、TNF-α、IL-2、IL-4、IFN-γ则较健康对照组升高。抑郁发作患者仅IL-6水平升高。除IL-4外，缓解期患者和健康受试者之间的细胞因子水平无显著差异。情绪症状与IL-6、IL-2呈正相关。讨论：这些结果表明躁狂症和抑郁症在较小程度上与促炎状态有关。这些变化似乎与情绪状态有关，因为细胞因子谱的变化在急性发作期间比在正常情绪中更明显。这项研究为研究免疫系统作为未来治疗开发的目标提供了进一步的支持。(C)2008 Elsevier B. V.保留所有权利。
Background: The neurobiology of bipolar disorder is not completely understood. Cytokines have received increasing attention as potential mediators of the interaction with immune, neuroendocrine system and specific pathways involved in mood, energy, and activity control. Previous reports have suggested the association of mania and bipolar depression with a proinflammatory state. However, they did not compare cytokine levels in all phases of bipolar disorder.Methods: Sixty-one bipolar patients were recruited for assessment of serum cytokine levels. Of these, 14 were in euthymic state, 23 and 24 were in manic and depressive episodes, respectively. A healthy comparison group included 25 healthy volunteers. Cytokines involved in Th1/Th2 balance, such as TNF-alpha, IL-2, IL-4, IL-6, IL-10, IFN-gamma, were examined by flow cytometry.Results: During mania, proinflammatory cytokines, IL-2, IL-4 and IL-6, were increased in comparison with healthy subjects. Patients in depressive episode showed only increased IL-6 levels. There were no significant differences in cytokine levels between patients in remission and healthy subjects, except for IL-4. Mood symptoms showed a positive correlation with IL-6 and IL-2.Discussion: These findings suggest that mania, and to a less extent, depression are associated with a proinflammatory state. These changes seem to be related to mood state, as changes in cytokine profile were more pronounced during acute episodes than in euthymia. This study provides further support to investigate the immune system as a target for future treatment development. (C) 2008 Elsevier B.V. All rights reserved.