Response of mammalian cells to metabolic stress; changes in cell physiology and structure/function of stress proteins.
Response of mammalian cells to metabolic stress; changes in cell physiology and structure/function of stress proteins.
复制标题
哺乳动物细胞对代谢应激的反应；
DOI：
10.1007/978-3-642-75875-1_2
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发表时间：
1991
影响因子：
--
通讯作者：
Mizzen,LA
中科院分区：
文献类型：
--
作者：
Welch,WJ;Kang,HS;Beckmann,RP;Mizzen,LA
为了应对局部环境的不利变化，所有生物体的细胞或组织都会增加一组称为热休克或应激蛋白的蛋白质的表达。总的来说，应激蛋白被认为在环境损害期间为细胞提供一定程度的保护，并促进因应激事件而受到干扰的代谢途径的修复和恢复。在过去的几年中，我们已经清楚地发现，大多数应激蛋白在未应激的细胞中都以相当高的水平存在，并且参与了许多非常基本和重要的生化途径。本综述讨论了经历代谢应激的哺乳动物细胞的细胞生理学的相关变化。此外，人们对各个应激蛋白的特性和可能的功能的讨论也给予了相当多的关注。
In response to adverse changes in their local environment, cells or tissues from all organisms increase the expression of a group of proteins referred to as heat shock or stress proteins. Collectively, the stress proteins are thought to provide the cell with some degree of protection during the environmental insult as well as facilitate the repair and recovery of metabolic pathways perturbed as a consequence of the stress event. Within the past few years it has become apparent that most all of the stress proteins are present in appreciable levels in the unstressed cell and are involved in a number of very basic and essential biochemical pathways. The present review has discussed pertinent changes in cell physiology in mammalian cells experiencing metabolic stress. In addition, considerable attention has been given to discussing the properties and possible functions of the individual stress proteins.