Enhancing effect of suspended particulate matter on the IgE antibody production in mice.
Enhancing effect of suspended particulate matter on the IgE antibody production in mice.
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悬浮颗粒物对小鼠 IgE 抗体产生的增强作用。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
Terumasa Miyamoto
中科院分区：
文献类型：
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作者：
Shigeru Takafuji;Shuji Suzuki;Kazuhiro Koizumi;Kenji Tadokoro;Haruo Ohashi;Masaharu Muranaka;Terumasa Miyamoto
悬浮颗粒物(SPM)悬浮在污染的环境大气中，长期吸入人体内，被认为对人体健康有深远的影响。本研究探讨了SPM对小鼠免疫球蛋白E抗体产生的促进作用。每隔3周经鼻腔注射卵白蛋白(OA)加SPM免疫的小鼠，其IgE抗体应答均高于单独用OA免疫的小鼠。当抗原剂量为0.25微克时，SPM的增强时间和增强幅度与常用佐剂灭活百日咳杆菌相当。即使是小剂量的SPM，如每隔3周给药0.25微克，对IgE抗体的产生也有促进作用。不能排除这样一种可能性，即人类在环境大气中自然接触SPM可能解释了日本污染地区花粉引起的过敏性鼻炎的高患病率。
Suspended particulate matter (SPM), suspended in the polluted environmental atmosphere, are perpetually inhaled into the human body and are considered to have profound effects on human health. This study investigated the enhancing effect of SPM on the IgE antibody production in mice. The IgE antibody responses in mice immunized with intranasal administration of ovalbumin (OA) plus SPM at 3-week intervals were higher than responses in the animals immunized with OA alone. When the dose of OA administered as an antigen was 0.25 microgram, the time course and magnitude of enhancement by SPM was comparable to those by killed Bordetella pertussis, a common adjuvant. SPM had an enhancing effect on IgE antibody production even in a small dose such as 0.25 microgram administered at 3-week intervals. The possibility cannot be excluded that the natural exposure of humans to SPM in the environmental atmosphere may explain the high prevalence rate of allergic rhinitis caused by pollens in polluted districts in Japan.