Aging alters the perception and physiological representation of frequency: evidence from human frequency-following response recordings.
Aging alters the perception and physiological representation of frequency: evidence from human frequency-following response recordings.
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DOI：
10.1016/j.heares.2009.11.010
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发表时间：
2010-06-01
期刊：
影响因子：
2.8
通讯作者：
Krishnan AR
中科院分区：
文献类型：
--
作者：
Clinard CG;Tremblay KL;Krishnan AR
老年人，即使临床上听力正常，相对于年轻人也有听觉感知缺陷。这种困难可能部分地与频率的神经表征的下降有关。本研究旨在探讨年龄对频率表征的行为和生理指标的影响。32名成年人（年龄22 - 77岁）参加了本实验，在倍频程频率0.25 - 8.0 kHz时听阈≤ 25 dB HL。频率辨别差阈（FDLs）在500和1000赫兹，使用两个间隔，两个选择的强迫选择程序。线性回归分析显示，随着年龄的增加，两种频率的FDL均显着下降。频率跟随反应（FFR）由500和1000 Hz短纯音引起，以及在这些FDL内和外的频率。在1000 Hz和略低于1000 Hz的频率下，FFR相位相干性和FFR振幅的线性回归显示随着年龄的增加而显著降低。因此，音高辨别力（通过FDL测量）和频率的神经表征（通过FFR反映）随着年龄的增长而下降。虽然感知和神经表征同时下降，但一个不能预测另一个。
Older adults, even with clinically normal hearing sensitivity, have auditory perceptual deficits relative to their younger counterparts. This difficulty may in part, be related to a decline in the neural representation of frequency. The purpose of this study was to examine the effect of age on behavioral and physiological measures of frequency representation. Thirty two adults (ages 22 – 77), with hearing thresholds ≤ 25 dB HL at octave frequencies 0.25 – 8.0 kHz, participated in this experiment. Frequency discrimination difference limens (FDLs) were obtained at 500 and 1000 Hz using a two-interval, two-alternative forced choice procedure. Linear regression analyses showed significant declines in FDLs at both frequencies as age increased. Frequency-following responses (FFRs) were elicited by 500 and 1000 Hz tonebursts, as well as at frequencies within and outside those FDLs. Linear regression of FFR phase coherence and FFR amplitude at frequencies at and slightly below 1000 Hz showed significant decreases as age increased. Therefore, pitch discrimination, as measured by FDLs, and neural representation of frequency, as reflected by FFR, declined as age increased. Although perception and neural representation concurrently declined, one was not predictive of the other.
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