Morphine antinociception elicited from the ventrolateral periaqueductal gray is sensitive to sex and gonadectomy differences in rats
Morphine antinociception elicited from the ventrolateral periaqueductal gray is sensitive to sex and gonadectomy differences in rats
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DOI：
10.1016/s0006-8993(98)01364-x
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发表时间：
1999-03-06
期刊：
影响因子：
2.9
通讯作者：
Bodnar, RJ
中科院分区：
文献类型：
--
作者：
Krzanowska, EK;Bodnar, RJ
在向侧脑室或吻侧腹内侧髓质（RVM）中央注射吗啡后，观察到性别差异，雄性大鼠比雌性大鼠表现出明显更强的抗感觉能力。本研究探讨了两性和成年性腺切除术后，吗啡诱导的（1-10 μ g）由腹外侧导水管周围灰质（vlPAG）引起的两种伤害性测量是否存在差异。假手术雄性大鼠（ED50 = 1.20 ~ 1.60 μ g）和去势雄性大鼠（ED50 = 1.08 ~ 1.09 μ g）在两项实验中均表现出比雌性大鼠更大的吗啡诱导抗痛觉强度和效力。发情期假手术雌性大鼠（ED50 = 50 μ g）对吗啡的敏感性明显低于去卵巢雌性大鼠（ED50 = 1.98 ~ 2.51 μ g）。因此，vlPAG，一个对含雌二醇的下丘脑位点和阿片肽之间的相互作用敏感的位点，引发吗啡诱导的抗痛觉，这对性别差异和成人性腺切除术敏感。(C) 1999 Elsevier Science B.V.版权所有
Sex differences have been observed in antinociception following central administration of morphine into either the lateral ventricles or rostral ventromedial medulla (RVM) such that male rats exhibit significantly greater antinociception than female rats. The present study examined whether sex and adult gonadectomy differences were observed in morphine-induced (1-10 mu g) antinociception elicited from the ventrolateral periaqueductal gray (vlPAG) on two nociceptive measures. Both sham-operated (ED50 = 1.20-1.60 mu g) and castrated (ED50 = 1.08-1.09 mu g) male rats displayed significantly greater magnitudes and potencies of morphine-induced antinociception on both tests than female rats. Sham-operated female rats tested during the estrous phase (ED50 = >50 mu g) were significantly less sensitive to morphine than ovariectomized female rats (ED50 = 1.98-2.51 mu g). Thus, the vlPAG, a site sensitive to interactions between estradiol-containing hypothalamic loci and opioid peptides, elicits morphine-induced antinociception which is sensitive to sex differences and adult gonadectomy. (C) 1999 Elsevier Science B.V. All rights reserved.