An early improvement threshold to predict response and remission in first-episode schizophrenia
An early improvement threshold to predict response and remission in first-episode schizophrenia
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DOI：
10.1192/bjp.bp.109.069328
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发表时间：
2010-06-01
影响因子：
10.5
通讯作者：
Riedel, M.
中科院分区：
文献类型：
--
作者：
Schennach-Wolff, R.;Seemueller, F. H.;Riedel, M.
背景早期改善被认为是重要的治疗在首发精神分裂症患者，但一个有效的定义仍然是outstanding.AimsTo制定一个有效的早期改善的定义，并测试其预测效度关于反应和缓解方法我们检查了188例首发精神分裂症住院患者。早期改善定义为第2周阳性和阴性症状量表（PANSS）总分的改善，反应为终点PANSS总分改善40%，缓解根据共识criterions.ResultsResultsReasonably早期改善的预测效度为第2周PANSS总分改善46%，缓解改善50（曲线下面积：反应0.707，缓解0.692）。估计的置信区间范围为26至62%PANSS减少反应和remission.ConclusionsPatients首次发作的精神分裂症应改善至少30%的PANSS总分在第2周，以实现反应和缓解。
BackgroundEarly improvement with treatment is thought to be important in patients with first-episode schizophrenia, yet a valid definition is still outstanding.AimsTo develop a valid definition of early improvement and test its predictive validity regarding response and remissionMethodWe examined 188 in-patients with first-episode schizophrenia. Early improvement was defined as improvement in Positive and Negative Syndrome Scale (PANSS) total score at week 2, response as a 40% PANSS total score improvement at end-point, and remission according to consensus criteria.ResultsReasonable predictive validity of early improvement was found for a 46% PANSS total score improvement at week 2 and a 50% improvement for remission (area under the curve: response 0.707, remission 0.692). Estimated confidence intervals ranged from 26 to 62% PANSS reduction for response and remission.ConclusionsPatients with a first episode of schizophrenia should improve by at least 30% in PANSS total score at week 2 to achieve response and remission.