Co-expression of ER-beta and HER2 associated with poorer prognosis in primary breast cancer.
Co-expression of ER-beta and HER2 associated with poorer prognosis in primary breast cancer.
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DOI：
10.25011/cim.v32i3.6114
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发表时间：
2009-06
期刊：
影响因子：
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通讯作者：
Wenbin Qui;L. Yue;A. Ding;Jian Sun;Yang Yao;Zan Shen;L. Fan
中科院分区：
文献类型：
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作者：
Wenbin Qui;L. Yue;A. Ding;Jian Sun;Yang Yao;Zan Shen;L. Fan
目的探讨雌激素受体(ER)- β和人表皮生长因子受体2 （HER2）在中国原发性乳腺癌患者中的共表达对预后的影响。方法对308例原发性乳腺癌手术患者的肿瘤标本进行评价。免疫组化法检测er - β和HER-2的表达。结果123例（40%）er - β阳性，58例（18.5%）HER2阳性。在58例HER2阳性患者中，44例er - β阳性，14例er - β阴性。er - β阳性与HER2阳性（75.9%，P=0.018）、er - α阳性（79.7%，P=0.023）、细胞分化差（77.2%，P=0.010）、绝经年龄或= 3cm肿瘤大小（67.2%，P=0.011）相关。结论单因素分析显示，er - β阳性和HER2阳性与较差的总生存期（OS）相关。在HER2阳性和HER2阴性亚组中，er - β阳性与较差的远处无病生存（DDFS）相关，但与OS无关，这意味着er - β可能与乳腺癌转移有关。
PURPOSE To assess the prognostic value of co-expression of estrogen receptor (ER)-beta and human epidermal growth factor receptor 2 (HER2) in primary breast cancer patients in China. METHODS Tumour specimens from 308 patients undergoing surgery for primary breast cancer were evaluated. Expression of ER-beta and HER-2 was investigated by the immunohistochemistry. RESULTS 123 patients (40%) were ER-beta positive and 58 (18.5 %) were HER2 positive. Among the 58 HER2 positive patients, 44 were ER-beta positive and 14 were ER-beta negative. ER-beta positive was associated with HER2 positive (75.9%, P=0.018) as well as ER-alpha positive (79.7%, P=0.023), poor cell differentiation (77.2% grade 2 or 3, P=0.010) and menopause age or = 3 cm tumour size (67.2%, P=0.011). CONCLUSION Both ER-beta positive and HER2 positive status was associated with poorer overall survival (OS) by univariate analysis. In both HER2 positive and HER2 negative subgroups, ER-beta positive was associated with poorer distant disease free survival (DDFS) but not OS, which implied that ER-beta might relate to metastasis in breast cancer.