Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study
Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study
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DOI：
10.1093/ajcn/76.2.390
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发表时间：
2002-08-01
影响因子：
7.1
通讯作者：
Jacques, PF
中科院分区：
文献类型：
--
作者：
McKeown, NM;Meigs, JB;Jacques, PF
背景资料：全谷物对心血管疾病风险的影响可能是通过多种途径介导的，例如，降低血脂和血压，增强胰岛素敏感性，改善血糖控制。目的：目的是在Fragrance Offspring研究队列中检查富含全谷物或精制谷物食物的饮食与疾病风险的几种代谢标志物之间的关联。设计：在一项对2941名受试者进行的横断面研究中，对全谷物摄入量和代谢风险标志物进行了评估。结果：在调整了潜在的混杂因素后，全谷物摄入量与体重指数呈负相关（（x）在条形图上：摄入量最低的五分位数为26.9，摄入量最高的五分位数为26.4;趋势P = 0.06），腰臀比（分别为0.92和0.91;趋势P = 0.005），总胆固醇（分别为5.20和5.09 mmol/L;趋势P = 0.06），LDL胆固醇（分别为3.16和3.04 mmol/L;趋势P = 0.02）和空腹胰岛素（分别为205和199 pmol/L;趋势P = 0.03）。在五分之一类别的精制谷物摄入量中，代谢危险因素浓度没有显着趋势。全麦摄入量与空腹胰岛素之间的负相关在超重参与者中最为显着。调整后的膳食纤维和Mg 2 O3.Conclusion：全谷物摄入量的增加可能会降低疾病的风险，通过有利的影响代谢危险因素之间的关联全谷物摄入量和空腹胰岛素衰减。
Background: The influence of whole grains on cardiovascular disease risk may be mediated through multiple pathways, eg, a reduction in blood lipids and blood pressure, an enhancement of insulin sensitivity, and an improvement in blood glucose control.Objective: The objective was to examine the association between diets rich in whole- or refined-grain foods and several metabolic markers of disease risk in the Framingham Offspring Study cohort.Design: Whole-grain intake and metabolic risk markers were assessed in a cross-sectional study of 2941 subjects.Results: After adjustment for potential confounding factors, whole-grain intake was inversely associated with body mass index ((x) over bar: 26.9 in the lowest and 26.4 in the highest quintile of intake; P for trend = 0.06), waist-to-hip ratio (0.92 and 0.91, respectively; P for trend = 0.005), total cholesterol (5.20 and 5.09 mmol/L, respectively; P for trend = 0.06), LDL cholesterol (3.16 and 3.04 mmol/L, respectively; P for trend = 0.02), and fasting insulin (205 and 199 pmol/L, respectively; P for trend = 0.03). There were no significant trends in metabolic risk factor concentrations across quintile categories of refined-grain intake. The inverse association between whole-grain intake and fasting insulin was most striking among overweight participants. The association between wholegrain intake and fasting insulin was attenuated after adjustment for dietary fiber and magnesium.Conclusion: Increased intakes of whole grains may reduce disease risk by means of favorable effects on metabolic risk factors.