Better safe than sorry-preventing mitotic segregation of meiotic chromosomes.
Better safe than sorry-preventing mitotic segregation of meiotic chromosomes.
复制标题
安全总比遗憾地阻止减数分裂染色体的有丝分裂分离更好。
DOI：
10.1101/gad.336164.119
复制
发表时间：
2020
影响因子：
10.5
通讯作者：
Dawson,DeanS
中科院分区：
文献类型：
--
作者：
Meyer,RégisE;Dawson,DeanS
染色体在有丝分裂和减数分裂中的独特分离模式部分取决于着丝粒，着丝粒是染色体上将它们附着在纺锤体微管上的结构。减数分裂中不适当的有丝分裂样染色体分离导致配子染色体数目不正确。Chen及其同事的新发现（pp. 209-225）在本期《基因与发育》中揭示了细胞进入减数分裂时如何重组其动粒。他们的结果描述了一套相互关联的机制，提供了多层保护，防止有丝分裂染色体分离模式遗留到减数分裂细胞中。
The distinctive segregation patterns of chromosomes in mitosis and meiosis are dictated in part by the kinetochores, the structures on chromosomes that attach them to the microtubules of the spindle. Inappropriate mitosis-like chromosome segregation in meiosis leads to gametes with incorrect chromosome numbers. New findings by Chen and colleagues (pp. 209–225) in this issue of Genes & Development reveal how cells restructure their kinetochores when they enter meiosis. Their results describe an interconnected set of mechanisms that provides multiple layers of protection from the carryover of mitotic chromosome segregation patterns into meiotic cells.