In search of molecular memory: experience-driven protein synthesis.
In search of molecular memory: experience-driven protein synthesis.
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寻找分子记忆：经验驱动的蛋白质合成。
DOI：
10.1007/pl00000618
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Fallon,JR
中科院分区：
文献类型：
--
作者：
Wells,DG;Fallon,JR
记忆的形成和维持是大脑最有趣的功能之一。人类的大脑具有非凡的能力，可以存储和检索多年甚至几十年的过去经验。最近，人们投入了大量的努力，将学习和记忆的过程减少到细胞和分子水平[见参考文献1]。潜在的逻辑是，如果我们能够理解单个神经元是如何记忆的，那么我们就可以将这种功能外推到位于大脑中涉及记忆形成和存储的区域的神经元组。其中一个位于内侧颞叶的区域被称为海马体。这种结构对于外显或陈述性记忆（回忆与人或地点有关的信息）尤其重要。蛋白质合成过程是长期（外显）记忆编码的关键事件。因此，大量的研究重点放在了这种经验驱动的蛋白质合成的分子基础上，希望它能阐明记忆的基础。脑中细胞间通讯的主要场所是突触。由于突触传递在大脑中对信息进行编码，记忆的印迹可能在于突触使用稳定的修改来记住其兴奋历史的能力。这种形式的突触可塑性是由Hebb在1949年提出的[3]，并且在20世纪70年代早期首次被实验描述为在强大的突触活动之后突触强度的持久增加[4，5]。布利斯及其同事在海马体中描述的长时程增强（现在称为长时程增强或LTP）已经成为我们目前关于记忆如何编码的理论的组成部分[6，7]。虽然以下讨论的大部分集中在LTP上，但重要的是要注意突触可塑性是一个双向过程，突触减弱或长期抑制（LTD）也可能在记忆中发挥作用[8，9]。
The formation and maintenance of memories is one of the most intriguing functions of the brain. The human brain has the remarkable ability to store and retrieve past experiences for years and in some instances decades. Of late, extensive effort has been put into reducing the process of learning and memory to the cellular and molecular level [see ref. 1]. The underlying logic is that if we can understand how an individual neuron remembers we might then extrapolate this function to groups of neurons residing in areas of the brain involved in memory formation and storage. One such area, residing in the medial temporal lobe, is called the hippocampus. This structure is especially important for explicit or declarative memory—the recall of information pertaining to people or places [2]. The process of protein synthesis is a critical event in the encoding of long-term (explicit) memory. Thus, a great deal of research emphasis has been placed on the molecular basis of this experience-driven protein synthesis in the hope that it will elucidate the foundations of memory. The principal loci of cell-cell communication in the brain are synapses. Since synaptic transmission encodes information in the brain, the engram for memory may lie in the ability of the synapse to use stable modifications to remember its excitatory history. This form of synaptic plasticity was postulated in 1949 by Hebb [3], and was first described experimentally in the early 1970s as a long-lasting increase in synaptic strength following robust synaptic activity [4, 5]. The long-lasting potentiation (now called long-term potentiation or LTP) thatBliss and colleagues described in the hippocampus has become integral to our present theories for how memories are encoded [6, 7]. Although much of the following discussion centers on LTP, it is important to note that synaptic plasticity is a bidirectional process and that a synaptic weakening or long-term depression (LTD) is likely to play a role in memory as well [8, 9].
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DOI：
--
发表时间：
1974
期刊：
American Journal of Optometry and Physiological Optics
影响因子：
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作者：
D. C. Allen
通讯作者：
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DOI：
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发表时间：
1942
期刊：
影响因子：
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作者：
V. Ellerbrockf;G. Fry
通讯作者：
G. Fry
影响因子：
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作者：
ERKELENS, CJ;COLLEWIJN, H
通讯作者：
COLLEWIJN, H
存在已知自然视网膜图像运动的视觉。
DOI：
10.1364/josaa.2.000226
发表时间：
1985
期刊：
Journal of the Optical Society of America. A, Optics and image science
影响因子：
--
作者：
Steinman,RM;Levinson,JZ;Collewijn,H;vanderSteen,J
通讯作者：
vanderSteen,J
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