Selective serotonin reuptake inhibitors and myocardial infarction
Selective serotonin reuptake inhibitors and myocardial infarction
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DOI：
10.1161/hc4101.097519
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发表时间：
2001-10-16
期刊：
影响因子：
37.8
通讯作者：
Kimmel, SE
中科院分区：
文献类型：
--
作者：
Sauer, WH;Berlin, JA;Kimmel, SE
背景-抑郁是心肌梗死（MI）的独立危险因素。选择性5-羟色胺再摄取抑制剂（SSRIs）可能会降低这种风险，通过衰减的阿托伐他汀介导的血小板活化，除了治疗depressionsituation.Methods和Results-A病例对照研究的第一次MI吸烟者30至65岁之间进行了为期28个月的所有68家医院在8个县的地区。病例为首次MI住院患者。使用随机数字拨号从同一地理区域随机选择每例病例约4名社区对照受试者。通过电话访谈获得关于抗抑郁药物使用的详细信息以及其他临床和人口统计学数据。共有653例首次心肌梗死患者和2990例对照受试者参加了研究。校正后，使用多变量logistic回归，包括年龄、性别、种族、教育、锻炼、每日吸烟量、体重指数、阿司匹林使用、MI家族史、就诊次数、冠心病、糖尿病、高血压或高胆固醇血症史，目前使用SSRI者与未使用者相比，MI的优势比为0.35（95%CI 0.18，0.68; P
Background-Depress ion is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this risk through attenuation of serotonin-mediated platelet activation in addition to treatment of depression itself.Methods and Results-A case-control study of first MI in smokers 30 to 65 years of age was conducted among all 68 hospitals in an 8-county area during a 28-month period. Cases were patients hospitalized with a first MI. Approximately 4 community control subjects per case were randomly selected from the same geographic area using random digit dialing. Detailed information regarding use of antidepressant medication as well as other clinical and demographic data were obtained by telephone interview. A total of 653 cases of first MI and 2990 control subjects participated. After adjustment, using multivariable logistic regression, for age, sex, race, education, exercise, quantity smoked per day, body mass index, aspirin use, family history of MI, number of physician encounters, and history of coronary disease, diabetes, hypertension, or hypercholesterolemia, the odds ratio for MI among current SSRI users compared with nonusers was 0.35 (95% CI 0.18, 0.68; P