Periodontal Homeostasis: From Vienna to Texas-A Century of Periodontal Research in the Spirit of Bernhard Gottlieb.
Periodontal Homeostasis: From Vienna to Texas-A Century of Periodontal Research in the Spirit of Bernhard Gottlieb.
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牙周稳态：从维也纳到德克萨斯州——本着伯恩哈德·戈特利布精神的一个世纪牙周研究。
DOI：
10.1089/scd.2019.0126
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发表时间：
2019
影响因子：
4
通讯作者：
Diekwisch,ThomasGH
中科院分区：
文献类型：
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作者：
Diekwisch,ThomasGH
1941年，伯恩哈德·戈特利布（Bernhard Gottlieb）逃离了维也纳的纳粹，在巴勒斯坦、纽约和密歇根州定居的尝试都失败后，他来到了德克萨斯州的达拉斯。在达拉斯，维也纳牙科研究所曾经强大的负责人相当孤立，周围只有几个忠实的崇拜者，没有他的著名学生巴林特·奥尔班、约瑟夫·彼得·魏曼和哈里·西切尔，他们当时已经在芝加哥找到了家。德克萨斯A&M牙科学院的前身贝勒牙科学院的校友认识到戈特利布的重要性，并授予他口腔病理学教授职位。戈特利布在达拉斯的新角色是在医学院教师离开休斯敦后为牙科学生提供基础科学教育。然而，戈特利布真正的遗产是他在口腔病理学和临床科学（最著名的是牙周病）之间建立口腔生物学作为一门新学科的作用。从1920年到1946年，Gottlieb发表了关于侵袭性牙周炎、牙周再生、牙根骨质和牙周韧带屏障作用的开创性研究。1942年，戈特利布是第一位发现仿生学潜力的牙科科学家，他提出“。如果这些关于牙骨质生物学的观点是正确的，那么我们的任务就是找出大自然是如何提供连续的牙骨质沉积的，并在这样做之后，模仿这个过程。Gottlieb也对骨稳态非常感兴趣，他认为牙槽骨吸收和附着体之间的平衡对附着体bbb的稳定性很重要。在Gottlieb的原始工作的基础上，德克萨斯州达拉斯的德克萨斯A&M牙科学院将于2019年8月7日至10日主办一场关于牙周稳态的会议，会议的主题包括牙周矿物质稳态、牙周免疫反应的稳态、牙周组织工程、微创治疗以及精准医学。本次会议的主题，牙周内稳态，是干细胞和祖细胞在组织维持、修复和再生中的作用的教科书范例：牙周干细胞控制牙周韧带的非矿化状态，因为牙周韧带被侧翼矿化组织牙槽骨和骨质所包围。成骨细胞和破骨细胞祖细胞平衡了模拟和塑造牙槽骨的合成代谢和分解代谢过程
Bernhard Gottlieb arrived in Dallas, TX, in 1941, after fleeing the Nazis in Vienna and after unsuccessful attempts to settle in Palestine, New York, and then Michigan [1]. In Dallas, the once powerful head of Vienna’s dental institute was fairly isolated, surrounded only by a few faithful admirers and without his famous students Balint Orban, Joseph-Peter Weinmann, and Harry Sicher, who by then had found a home in Chicago [2, 3]. Alumni of Texas A&M College of Dentistry’s predecessor, Baylor College of Dentistry, recognized Gottlieb’s significance and bestowed him with a professorship in oral pathology. Gottlieb’s new role in Dallas was to provide basic sciences education for dental students after the departure of the medical school faculty to Houston. However, Gottlieb’s true legacy was his role in establishing oral biology as a new discipline at the interface between oral pathology and clinical sciences, most notably periodontics. From 1920 to 1946, Gottlieb published seminal studies on aggressive periodontitis, periodontal regeneration, root cementum, and the barrier role of the periodontal ligament [4]. In 1942, Gottlieb was the first dental scientist to uncover the potential of biomimetics when he suggested that ‘‘. if these ideas about the biology of the cementum are correct, it is then our task to find out just how nature provides for continuous cementum deposition, and having done so, to imitate the procedure’’[5]. Gottlieb also was keenly interested in bone homeostasis as he believed that the balance between alveolar bone resorption and apposition was important for the stability of the attachment apparatus [6]. Expanding on Gottlieb’s original work, Texas A&M College of Dentistry in Dallas, TX, is hosting a conference on periodontal homeostasis from August 7 to 10, 2019, featuring a broad range of topics from periodontal mineral homeostasis, homeostasis of the periodontal immune response, periodontal tissue engineering, and minimally invasive therapy, as well as precision medicine.The topic of this conference, periodontal homeostasis, is a textbook example for the role of stem cells and progenitors in tissue maintenance, repair, and regeneration: Periodontal stem cells control the nonmineralized state of the periodontal ligament as it is surrounded by the flanking mineralized tissues alveolar bone and cementum [7]. Osteoblast and osteoclast progenitors balance the anabolic and catabolic processes that model and shape the alveolar bone