Dietary 25-hydroxycholecalciferol supplementation improves performance, immunity, antioxidant status, intestinal morphology, and bone quality in weaned piglets.
Dietary 25-hydroxycholecalciferol supplementation improves performance, immunity, antioxidant status, intestinal morphology, and bone quality in weaned piglets.
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DOI：
10.1002/jsfa.10889
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发表时间：
2020-10
影响因子：
4.1
通讯作者：
Lianhua Zhang;Sujie Liu;X. Piao
中科院分区：
文献类型：
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作者：
Lianhua Zhang;Sujie Liu;X. Piao
背景25-羟基胆钙化醇（25-hydroxycholecalciferol，25 OHD 3）是一种新型饲料添加剂，在猪营养中有可能替代维生素D3。本研究旨在探讨不同剂量25 OHD 3对仔猪生产性能、免疫功能、抗氧化能力、肠道形态和骨质量的影响。结果随着日粮25 OHD 3添加量的增加，1-14日龄的日增重（ADG）呈二次曲线增加（P < 0.05），整个试验期的ADG呈二次曲线增加（P = 0.06）。随着25 OHD 3添加量的增加，血清25 OHD 3水平和血清谷胱甘肽过氧化物酶（GSH-Px）活性均显著升高（线性效应，P < 0.05）。在第14天，血清免疫球蛋白A（伊加）随着膳食25 OHD 3补充的增加而增加（线性和二次效应，P < 0.05）。28日龄时，随着25 OHD 3添加量的增加，血清伊加水平呈线性升高（P <0.05），补体C3水平呈线性降低（P < 0.05）。小肠粘膜GSH-Px活性随25 OHD 3添加量的增加而升高（二次效应，P < 0.05）。随着25 OHD 3添加量的增加，空肠绒毛高度（P = 0.06）和绒毛高度与隐窝深度之比（P = 0.07）呈二次曲线增加趋势，回肠绒毛高度与隐窝深度之比也呈线性和二次曲线增加（P < 0.05）。此外，日粮中添加25 OHD 3能显著提高胫骨和股骨的断裂强度（二次效应，P < 0.05）。结论日粮中添加25 OHD 3可部分改善断奶仔猪的生产性能、免疫力、抗氧化能力、肠道形态和骨骼特性。本文受版权保护。All rights reserved.
BACKGROUND 25-hydroxycholecalciferol (25OHD3 ) is a new feed additive, which is a potential alternative of vitamin D3 in swine nutrition. The objective of this study was to determine the effects of different doses of 25OHD3 supplementation on performance, immunity, antioxidant capacity, intestinal morphology and bone quality in piglet model. RESULTS As dietary 25OHD3 supplementation increased, average daily gain (ADG) was improved (P < 0.05) quadratically during days 1-14, and tended to be increased (P = 0.06) quadratically during overall period. Increasing 25OHD3 supplementation increased (linear effect, P < 0.05) serum 25OHD3 level and serum glutathione peroxidase (GSH-Px) activity. On day 14, serum immunoglobulin A (IgA) was increased (linear and quadratic effects, P < 0.05) as dietary 25OHD3 supplementation increased. On day 28, serum IgA level was higher (P < 0.05) linearly and complement 3 (C3) level was reduced (P < 0.05) linearly as dietary supplementation of 25OHD3 increased. Mucosal GSH-Px activity of small intestine was higher (quadratic effect, P < 0.05) with increasing 25OHD3 supplementation. Jejunal villus height (P = 0.06) and villus height to crypt depth ratio (P = 0.07) tended to be increased quadratically, as well as villus height to crypt depth ratio of ileum were increased (P < 0.05) linearly and quadratically with increasing 25OHD3 supplementation. In addition, dietary supplementation of increasing level of 25OHD3 increased (quadratic effect, P < 0.05) breaking strength of tibias and femurs. CONCLUSION Increasing dietary 25OHD3 supplementation partly improved performance, immunity, antioxidant status, intestinal morphology, and bone properties of weaned piglets. This article is protected by copyright. All rights reserved.