Prediction of postpartum onset of rheumatoid arthritis
Prediction of postpartum onset of rheumatoid arthritis
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DOI：
10.1136/ard.57.8.460
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发表时间：
1998-08-01
影响因子：
27.4
通讯作者：
Amino, N
中科院分区：
文献类型：
--
作者：
Iijima, T;Tada, H;Amino, N
目的探讨产后类风湿性关节炎（RA）发病的预测因素。方法对2547例健康孕妇进行前瞻性研究，探讨血清类风湿因子（RF）与产后RA发病的关系。观察了用抗人IgG乳胶凝集试验（Latex test）和抗兔IgG血凝试验（RAHA test）检测早孕妇女的风湿因子，结果：乳胶凝集试验阳性26例（1.0%），RAHA试验阳性64例（2.5%）。对2547例孕妇中410例进行了产后1年的随访。401例无RF或在Latex试验或RAHA试验中仅有一个RF的受试者在分娩后均未发生RA。两个（22.2%）的9名受试者与两个RF开发RA在产后一个月和三个月，分别。短暂性关节痛产后12个月内发现在三个9（33.3%）的主题与RF和这种患病率显着高于RF阴性subjects（8.1%）。结论产后发病的RA被发现在至少2 2547例健康受试者（0.08%）和发病预测类风湿因子阳性试验。
Objective-To investigate the prediction of the postpartum onset of rheumatoid arthritis (RA).Methods-Two thousand five hundred and forty seven healthy pregnant subjects were examined prospectively and the relation between serum rheumatoid factors (RF) and postpartum onset of RA. was observed. Rheumatoid factors were measured in early pregnancy by the antihuman IgG latex agglutination test (Latex test) and antirabbit IgG haemagglutination test (RAHA test).Results-Latex test and RAHA test were positive in 26 (1.0%) and 64 (2.5%) pregnant subjects, respectively. Four hundred and ten subjects of 2547 pregnant women could be followed up for one year after delivery. None of 401 subjects without RF, or with only one RF on either Latex test or RAHA test, developed RA after delivery. Two (22.2%) of nine subjects with both RFs developed RA at one and three months postpartum, respectively. Transient arthralgia was found within 12 months postpartum in three of nine (33.3%) subjects with both RFs and this prevalence was significantly higher than that in RF negative subjects (8.1%).Conclusion-Postpartum onset of RA was found in at least 2 of 2547 healthy subjects (0.08%) and onset was predicted by positive test for rheumatoid factors.