Alcohol consumption and mortality in Japan: The Miyagi Cohort Study
Alcohol consumption and mortality in Japan: The Miyagi Cohort Study
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DOI：
10.2188/jea.14.s18
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发表时间：
2004-02-01
影响因子：
4.7
通讯作者：
Hisamichi, S
中科院分区：
文献类型：
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作者：
Nakaya, N;Kurashima, K;Hisamichi, S
背景：我们研究了日本男性和女性饮酒与全因死亡率之间的关系。方法：从 1990 年 6 月到 8 月，日本北部农村宫城县 14 个市镇的总共 39,076 名受试者（20,660 名男性和 18,416 名女性）（40-64 岁）完成了一份自填问卷，其中包括有关饮酒和各种健康习惯的信息。在 11 年的跟踪调查中，我们确认了 1,879 人死亡（1,335 名男性和 544 名女性）。我们使用 Cox 比例风险回归根据饮酒类别来估计全因死亡的相对风险 (FIR)，并根据年龄、教育程度、婚姻状况、慢性病史、体重指数、吸烟、步行和饮食变量进行调整。 结果：在男性中，过去饮酒者的全因死亡风险显着高于从不饮酒者（多变量 RR，1.86；95% 置信区间 [CI]， 1.50-2.29）。目前饮酒的男性中，饮酒量与全因死亡风险之间存在剂量反应关系：相对于从不饮酒者 (95% CI)，当前饮酒者的多变量 RR 分别为 1.10 (0.90-1.33)、1.17 (0.96-1.42)、1.16 (0.96-1.40) 和 1.62 (1.32-1.99)。每天饮酒量分别低于 22.8 克、22.8-45.5 克、45.6-68.3 克和 68.4 克或更多的饮酒者（P 为趋势
BACKGROUND: We examined the association between alcohol consumption and all-cause mortality in Japanese men and women.METHODS: From June through August 1990, a total of 39,076 subjects (20,660 men and 18,416 women) in 14 municipalities of Miyagi Prefecture in rural northern Japan (40-64 years of age) completed a self-administered questionnaire that included information about alcohol consumption and various health habits. During 11 years of follow-up, we identified 1,879 deaths (1,335 men and 544 women). We used Cox proportional-hazards regression to estimate relative risk (FIR) of all-cause mortality according to categories of alcohol consumption and to adjust for age, education, marital status, past histories of chronic diseases, body mass index, smoking, walking and dietary variables.RESULTS: Among men, the risk for all-cause mortality was significantly higher in past drinkers than never-drinkers (multivariate RR, 1.86; 95% confidence interval [CI], 1.50-2.29). There was a dose-response association between alcohol consumption and the risk of all-cause mortality among current drinking men: multivariate RRs in reference to never-drinkers (95% CI) were 1.10 (0.90-1.33), 1.17 (0.96-1.42), 1.16 (0.96-1.40), and 1.62 (1.32-1.99) in current drinkers who consumed less than 22.8 g, 22.8-45.5 g, 45.6-68.3 g, and 68.4 g or more alcohol per day, respectively (P for trend