Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance.
Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance.
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DOI：
10.1016/j.addr.2021.02.006
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发表时间：
2021-05
影响因子：
16.1
通讯作者：
Repka MA
中科院分区：
文献类型：
--
作者：
Bandari S;Nyavanandi D;Dumpa N;Repka MA
近年来，人们对3D打印用于制药应用的兴趣有所增加。与其他3D打印技术相比，基于热熔融挤压(HME)的熔融沉积成型(FDM)3D打印技术在以患者为中心的剂量方面得到了最广泛的研究。HME技术可以与FDM3D打印相结合，作为一种连续的制造工艺。然而，要建立HME偶联的FDM3D打印，必须研究关键的药物聚合物、配方和工艺参数。这些进展将引领为个性化治疗开发连续给药系统的道路。本简要概述对药物添加剂制造、热熔融挤压和熔融沉积成型3D打印技术进行了分类，重点介绍了HME和FDM3D打印工艺的耦合。它还提供了对成功的HME耦合FDM系统的关键材料特性、工艺和设备参数以及限制的见解。
Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively investigated for patient-focused dosage. HME technology can be coupled with FDM 3D printing as a continuous manufacturing process. However, the crucial pharmaceutical polymers, formulation and process parameters must be investigated to establish HME-coupled FDM 3D printing. These advancements will lead the way towards developing continuous drug delivery systems for personalized therapy. This brief overview classifies pharmaceutical additive manufacturing, Hot Melt Extrusion, and Fused Deposition Modeling 3D printing techniques with a focus on coupling HME and FDM 3D printing processes. It also provides insights on the critical material properties, process and equipment parameters and limitations of successful HME-coupled FDM systems.
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