Prostatic carcinoma: treatment of advanced cases with intravenous diethylstilbestrol diphosphate.
Prostatic carcinoma: treatment of advanced cases with intravenous diethylstilbestrol diphosphate.
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前列腺癌：静脉注射二磷酸己烯雌酚治疗晚期病例。
DOI：
10.1016/s0022-5347(17)67313-0
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发表时间：
1955
期刊：
影响因子：
--
通讯作者：
L. Prendergast
中科院分区：
文献类型：
--
作者：
R. Flocks;H. Marberger;B. Begley;L. Prendergast
方法已有66名前列腺癌患者服用了这种化合物。其中34个对通常的雌激素没有反应或变得无效。12例晚期患者以前没有接受过激素治疗。在20例病情较轻的患者中，这种药物被用作其他治疗的辅助药物。己烯雌酚二磷酸的剂量从250毫克不等。至1250毫克。(安瓶含250毫克。在5毫升稀释液中，平均剂量为500毫克，静脉输注5%等渗盐水或5%葡萄糖水，总容量为200至500毫升。给药速度平均为每小时300毫升，一般每天输注一次或两次。根据临床反应的快慢，一个疗程从普通的5天到特殊的20天不等。重复的课程通常是每月一次。疗程数从1个到11个不等，其中12名患者有4个或更多个疗程。38名患者只有一个疗程；给定患者的最高总剂量为31,500毫克。
METHODSixty-six patients with proven prostatic carcinoma have been given this compound. Thirty-four of these had failed to respond or had become refractory to the usual estrogens. Twelve advanced cases had had no previous hormonal therapy. In twenty with less advanced disease, this drug was used as an adjunct to other therapy.Diethylstilbestrol diphosphate was administered in doses ranging from 250 mg. to 1250 mg.(ampules contained 250 mg. in 5 ml. diluent), average dose being 500 mg., given in an intravenous infusion of isotonic saline or dextrose 5 per cent in water, the total volume of which ranged from 200 to 500 ml. The rate of administration averaged 300 ml. per hour, and generally one, or perhaps two, infusions were given daily. A course of therapy ranged from the common of 5 days to the exceptional of 20 days, depending upon the rapidity of the clinical response. Repeated courses were given usually at monthly intervals. Number of courses of therapy varied from one to eleven, twelve of the patients having had four or more courses. Thirty-eight of the total patients had only a single course; the highest total dose in a given patient was 31,500 mg.