Parkinson's disease: Are gut microbes involved?
Parkinson's disease: Are gut microbes involved?
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DOI：
10.1152/ajpgi.00058.2020
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发表时间：
2020-11-01
影响因子：
4.5
通讯作者：
Kashyap, Punta C.
中科院分区：
文献类型：
--
作者：
Bhattarai, Yogesh;Kashyap, Punta C.
帕金森病（PD）是一种常见的神经退行性疾病，其特征在于运动和胃肠（GI）缺陷。尽管其患病率，PD的病理生理学还没有得到很好的理解。最近的研究强调了肠道微生物群在神经系统疾病中的作用。在这篇综述中，我们总结了肠道微生物群在PD病理生理学中的潜在作用。我们首先描述了肠道微生物群如何受到易患PD的因素的影响，例如环境毒素，衰老和宿主遗传学。然后，我们强调了肠道微生物群对PD病理生理学机制的影响，包括破坏微生物群肠脑轴（GBA），屏障功能障碍和免疫功能障碍。现在将肠道微生物群和PD之间的联系联系起来以建立因果关系还为时过早，专注于研究肠道微生物群和相关代谢物对GBA，Harrier功能障碍和免疫激活之间的相互关系的实验对于填补空白至关重要。
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor and gastrointestinal (GI) deficits. Despite its prevalence, the pathophysiology of PD is not well understood. Recent studies highlight the role of gut microbiota in neurological disorders. In this review, we summarize the potential role of gut microbiota in the pathophysiology of PD. We first describe how gut microbiota can be influenced by factors predisposing individuals to PD, such as environmental toxins, aging, and host genetics. We then highlight the effect of gut microbiota on mechanisms implicated in the pathophysiology of PD, including disrupted microbiota gut brain axis (GBA), barrier dysfunction, and immune dysfunction. It is too early to connect the dots between gut microbiota and PD to establish causation, and experiments focused on investigating interrelationship between gut microbiota and associated metabolites on GBA, harrier dysfunction, and immune activation will be crucial to fill in the gaps.