EXPERIMENTAL HYPERTHYROIDISM AND ADRENOCORTICAL FUNCTION IN THE RAT.
EXPERIMENTAL HYPERTHYROIDISM AND ADRENOCORTICAL FUNCTION IN THE RAT.
复制标题
大鼠实验性甲状腺机能亢进和肾上腺皮质功能。
DOI：
10.1210/endo-74-4-509
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发表时间：
1964
期刊：
影响因子：
4.8
通讯作者：
J. Grodin
中科院分区：
文献类型：
--
作者：
S. A. D ANGELO;J. Grodin
雄性和雌性大鼠长期给予大剂量三碘甲腺原氨酸(T3)(40，25μg；3-36天)可引起肾上腺皮质的过度活动，表现为血浆和肾上腺皮质激素浓度的显著升高以及腺体的肥大。重度甲亢动物肾上腺中抗坏血酸和皮质酮浓度呈负相关。随着T3剂量的增加，肾上腺抗坏血酸浓度持续下降(14-24%)，而腺体和血浆中的皮质酮水平分别增加2-4倍和40-80%。然而，男性增大的肾上腺中抗坏血酸含量显著增加。结论：在甲亢动物中，肾上腺皮质分泌增加，这种分泌至少可以维持几周。实验性甲状腺功能亢进症患者肾上腺皮质激素分泌与其抗坏血酸含量无定量关系。(内分泌学74：509,1964)
Chronic administration of triiodothyronine (T3) in high daily doses (40, 25 μg; 3–36 days) to male and female rats induced hyperactivity of the adrenal cortex, as indicated by marked increases in corticoid concentrations of plasma and adrenal and by hypertrophy of the gland. An inverse relationship was found between ascorbic acid and corticosterone concentration in adrenals of severely hyperthyroid animals. Adrenal ascorbic acid concentration was consistently reduced (14–24%) with higher doses of T3, while corticosterone levels in gland and plasma increased 2- to 4-fold and 40–80%, respectively. Ascorbic acid content of enlarged adrenals in the male increased significantly, however. It is concluded that in the hyperthyroid animal increased adrenocortical secretion occurs which can be maintained for at least several weeks. Cortical hormone elaboration by the adrenal in experimental hyperthyroidism bears no quantitative relationship to its ascorbic acid content. (Endocrinology 74: 509, 1964)