Effect of magnetite nanoparticles on living rate of MCF-7 human breast cancer cells
Effect of magnetite nanoparticles on living rate of MCF-7 human breast cancer cells
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DOI：
10.1016/j.colsurfb.2012.03.008
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发表时间：
2012-06-15
影响因子：
5.8
通讯作者：
Osaka, Tetsuya
中科院分区：
文献类型：
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作者：
Baba, Daisuke;Seiko, Yasuhiro;Osaka, Tetsuya
超顺磁性和铁磁性的磁铁矿纳米粒子，直径分别为约13和44 nm，合成和它们的摄取量和加热效率进行了评估，应用于磁热疗。两种纳米颗粒具有几乎相同的zeta-电位（+10.2mV）和流体动力学尺寸（类似于1 μ m），并且在它们加入培养基后18小时，它们的摄取量没有显著差异。内化后，铁磁性纳米颗粒纳入人乳腺癌细胞（MCF-7）显示出更高的加热效率比超顺磁性纳米颗粒时，外部磁场（4千瓦，250千赫）高到足以产生热的磁滞损耗，然后细胞死亡的MCF-7与高铁磁性纳米颗粒含量。(C)2012爱思唯尔有限公司版权所有。
Superparamagnetic and ferromagnetic magnetite nanoparticles, with diameters of approximately 13 and 44 nm, respectively, were synthesized and their uptake amount and heating efficiency were evaluated for application to magnetic hyperthermia. Both nanoparticles had almost the same zeta-potential (+10.2 mV) and hydrodynamic size (similar to 1 mu m) and there was no significant difference in their uptake amount 18 h after they were added to the medium. After internalization, the ferromagnetic nanoparticles incorporated in human breast cancer cells (MCF-7) showed a higher heating efficiency than the superparamagnetic nanoparticles when an external magnetic field (4 kW, 250 kHz) high enough to produce heat by hysteresis loss was applied, followed by cellular death of MCF-7 with high ferromagnetic nanoparticle content. (C) 2012 Elsevier B.V. All rights reserved.