Fibroblast Growth Factor 23 Is Associated With Subclinical Cerebrovascular Damage The Northern Manhattan Study
Fibroblast Growth Factor 23 Is Associated With Subclinical Cerebrovascular Damage The Northern Manhattan Study
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DOI：
10.1161/strokeaha.115.012379
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发表时间：
2016-04-01
期刊：
影响因子：
8.3
通讯作者：
Wolf, Myles
中科院分区：
文献类型：
--
作者：
Wright, Clinton B.;Shah, Nirav H.;Wolf, Myles
背景和目的成纤维细胞生长因子 23 (FGF23) 升高可调节磷酸盐稳态，并与死亡率、心血管事件和中风相关。然而，FGF23 作为亚临床脑血管损伤的危险因素的作用尚不清楚。方法我们使用多变量线性和逻辑回归来连续和按四分位数评估 FGF23 与白质高信号体积（以颅内体积百分比 (%ICV) 表示）和基于社区的无中风样本中的亚临床脑梗死 (SBI) 之间的关联。结果 有 1170 名无中风的北曼哈顿研究(NOMAS) 参与者提供 FGF23 水平以及白质高信号体积和 SBI 的定量磁共振成像数据。与最低四分位数（范围=15-49 RU/mL）的参与者相比，FGF23水平处于最高四分位数（范围=85-1425 RU/mL）的参与者具有更大的白质高信号体积（=0.19%ICV；95%CI，0.04-0.33%ICV；P=0.01），并根据人口统计、血管危险因素和估计肾小球滤过率进行调整。这些发现对于那些没有慢性肾脏疾病证据的人来说仍然很重要（估计肾小球滤过率）
Background and Purpose Elevated fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and is linked with mortality, cardiovascular events, and stroke. However, the role of FGF23 as a risk factor for subclinical cerebrovascular damage is unclear.Methods We used multivariable linear and logistic regression to evaluate associations between FGF23, continuously and by quartiles, with white matter hyperintensity volume, expressed as percent intracranial volume (%ICV), and subclinical brain infarction (SBI) in a community-based stroke-free sample.Results There were 1170 stroke-free Northern Manhattan Study (NOMAS) participants with FGF23 levels and quantitative magnetic resonance imaging data on white matter hyperintensity volume and SBI. Participants with FGF23 levels in the top quartile (range=85-1425 RU/mL) had greater white matter hyperintensity volume (=0.19 %ICV; 95% CI, 0.04-0.33 %ICV; P=0.01) compared with those in the lowest quartile (range=15-49 RU/mL), adjusted for demographics, vascular risk factors, and estimated glomerular filtration rate. These findings remained significant in those without evidence of chronic kidney disease (estimated glomerular filtration rate