Cancer Progress and Priorities: Uterine Cancer.
Cancer Progress and Priorities: Uterine Cancer.
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癌症进步和优先事项：子宫癌。
DOI：
10.1158/1055-9965.epi-18-0264
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Brinton LA
中科院分区：
文献类型：
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作者：
Felix AS;Brinton LA
背景子宫体癌是美国妇女最常见的侵袭性妇科肿瘤。子宫内膜癌占所有子宫癌的约90%，对子宫内膜癌的研究已经确定了许多风险因素，其中许多似乎反映了在缺乏足够孕酮的情况下雌激素水平高。最近的进展表明，这种疾病的病因是异质性的，至少包括两个主要的亚组。这种异质性延伸到发病率和生存率的重要种族差异，可能部分归因于遗传因素。
BackgroundUterine corpus cancer is the most common invasive gynecologic cancer among US women. Studies of endometrial cancers, which comprise approximately 90% of all uterine cancers, have identified numerous risk factors, many of which appear to reflect high levels of estrogens in the absence of sufficient progesterone. Recent advances have indicated that the disease is etiologically heterogeneous, consisting of at least two major subgroups. This heterogeneity extends to important racial differences in both incidence and survival, possibly partially attributable to genetic factors.