Rhodium-catalyzed enantioselective diboration of simple alkenes
Rhodium-catalyzed enantioselective diboration of simple alkenes
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DOI：
10.1021/ja035851w
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发表时间：
2003-07-23
影响因子：
15
通讯作者：
Morken, JP
中科院分区：
文献类型：
--
作者：
Morgan, JB;Miller, SP;Morken, JP
直接作用于廉价的未活化烯烃的对映选择性催化反应对于制备手性有机结构单元和新材料非常有用。虽然已经开发了许多此类工艺，但我们满足对廉价立体化学复杂材料日益增长的需求的能力将需要显着扩展实用的催化不对称反应方法。在这方面，为了同时解决催化烯烃转化中存在的许多问题，开发了铑催化的对映选择性二硼化反应。该方法提供了对映体富集的反应性双金属化中间体，其可以转化为各种双官能反应产物。
Enantioselective catalytic reactions that operate directly on inexpensive unactivated alkenes are extraordinarily useful for the preparation of chiral organic building blocks and new materials. While a number of such processes have been developed, our ability to meet the intensifying demand for inexpensive stereochemically complex materials will require a significant expansion of practical catalytic asymmetric reaction methodology. In this regard, the rhodium-catalyzed enantioselective diboration reaction has been developed in order to address a number of extant problems in catalytic alkene transformation simultaneously. This process provides an enantiomerically enriched reactive dimetalated intermediate which can be converted to a variety of difunctional reaction products.